{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T15:06:36Z","timestamp":1784905596578,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically evaluate the efficacy of platelet\u2010rich plasma (PRP) in treating anal fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, and Cochrane Library databases were systematically searched for randomized controlled studies (RCTs) and case\u2010control studies published before June 2021 on evaluating the efficacy of platelet\u2010rich plasma (PRP) in treating anal fistula. References of the journals were manually searched for relevant studies. Literature search, screening, data extraction, and bias assessment were carried out by two researcher independently. Stata13.0 and RevMan 5.3 software were used for statistical analysis of the cure rate and recurrence rate of anal fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6 case\u2010control studies and 3 RCTs involving 289 patients were included. Meta\u2010analysis showed that the pooled cure rate of all studies was 65% (95% CI 0.53\u20130.77), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.000, and the pooled recurrence rate of all studies was 12% (95% CI 0.08\u20130.17).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Platelet\u2010rich plasma is safe and effective in treating anal fistula and should be promoted and further studied in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14760","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T10:29:35Z","timestamp":1642674575000},"page":"4559-4566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Meta\u2010analysis of platelet\u2010rich plasma therapy for anal fistula"],"prefix":"10.1111","volume":"21","author":[{"given":"Qinghua","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Anorectal Surgery Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Jiangxi Hospital of Integrated Traditional Chinese and Western Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anorectal Surgery Wuyi Hospital of Traditional Chinese Medicine  Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31823122b3"},{"issue":"4","key":"e_1_2_9_3_1","first-page":"219","article-title":"Fistula\u2010in\u2010ano in a defined population. 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