{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:37:51Z","timestamp":1792085871883,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T00:00:00Z","timestamp":1645142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Androgenetic alopecia is defined as a patterned hair loss resulting from the effect of androgen on hair follicles and characterized by non\u2010scarring, progressive miniaturization of the hair follicles. Minoxidil and finasteride are regarded as the first\u2010line treatments with antiandrogens and flutamide are considered as the alternative choices. In the current study, we evaluated the efficacy of combination therapy with topical 2%flutamide plus 5% minoxidil vs. %5\u00a0minoxidil alone in the treatment of the androgenetic alopecia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>This was a randomized, double\u2010blinded clinical trial in 40 patients with androgenetic alopecia. Patients were randomized to receive either topical minoxidil vs. topical flutamide plus minoxidil for 6\u00a0months. At the end of study, patients were compared regarding mean hair density and mean hair thickness and patient's satisfaction. Collected data were analyzed using <jats:italic>t<\/jats:italic>\u2010test, Ki square, and Kolmogorov\u2013Smirnov tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical flutamide plus minoxidil solution was significantly more effective than minoxidil in terms of hair density, hair thickness, and patient's satisfaction (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical hydroalcoholic solution of flutamide plus minoxidil may be promising treatment for the androgenetic alopecia. To better evaluate the efficacy of topical flutamide, more prolonged studies with higher number of patients and use of different vehicles and different ingredients are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14788","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T18:18:05Z","timestamp":1644776285000},"page":"4447-4453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comparison between \u201c5% minoxidil plus 2% flutamide\u201d solution vs. \u201c5% minoxidil\u201d solution in the treatment of androgenetic alopecia"],"prefix":"10.1111","volume":"21","author":[{"given":"Gita","family":"Faghihi","sequence":"first","affiliation":[{"name":"Dermatology Department Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0206-0352","authenticated-orcid":false,"given":"Fariba","family":"Iraji","sequence":"additional","affiliation":[{"name":"Dermatology Department Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-7037","authenticated-orcid":false,"given":"Amir Hossein","family":"Siadat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Saber","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center School of Medicine Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Jelvan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh Sadat","family":"Hoseyni","sequence":"additional","affiliation":[{"name":"Isfahan University of Medical Sciences  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,18]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"15","article-title":"Androgenetic alopecia","volume":"149","author":"Piraccini BM","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"issue":"269","key":"e_1_2_11_3_1","first-page":"2315","article-title":"Comparing the efficiency of combination of minoxidil solution and tacrolimus cream with minoxidil solution alone in the treatment of alopecia areata","volume":"31","author":"Iraj F","year":"2014","journal-title":"J Isfahan Med Sch"},{"key":"e_1_2_11_4_1","unstructured":"CranwellW SinclairR.Male androgenetic alopecia. 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