{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:34:37Z","timestamp":1783632877045,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is a chronic inflammatory illness that affects 2%\u20133% of the world's population. Granulysin (GNLY), along with granzyme and perforin, is a cytolytic antimicrobial peptide (AMP) released from the granules of both natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). By immunohistochemistry, it has been shown that GNLY expression increases in psoriasis lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our work aimed to reveal the potential effect of GNLY gene polymorphism and its association with psoriasis pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control research included 25 patients with psoriasis vulgaris and 25\u00a0healthy people who were age and gender matched. History taking and medical examination were done for all patients. Venous blood samples were withdrawn, DNA was extracted, and real\u2010time PCR was done.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was an insignificant difference between psoriasis cases and controls as regards gene sequence (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). The polymorphism of GNLY gene regarding genotype distribution G\/G was detected in seven patients with psoriasis (28%) and in only two controls (8%). This clarifies that GNLY rs 7908\u00a0G\/G gene polymorphism may be a strong diagnostic tool for psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with psoriasis, the GNLY rs7908\u00a0CC genotype alongside with C allele played a preventative function and reduced disease severity (as shown by PASI score). Detection of GG genotype points out that a psoriatic case will run a progressive course, will have a severe pattern in the future, and will develop multiple site affection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14792","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T16:24:22Z","timestamp":1642955062000},"page":"4805-4809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["GNLY gene polymorphism: A potential role in understanding psoriasis pathogenesis"],"prefix":"10.1111","volume":"21","author":[{"given":"Hesham Nabil","family":"Khalid","sequence":"first","affiliation":[{"name":"Dermatology, Andrology &amp; STDs department Faculty of Medicine Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Abd Elsattar","family":"Elghobashy","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology department Faculty of Medicine Menoufia University  Shebin El\u2010Kom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1669-1865","authenticated-orcid":false,"given":"Asmaa Nagy","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Resident of Dermatology, Andrology &amp; STDs, at Ministry of Health  Al\u2010Mahala El\u2010Kobra Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.2.239"},{"key":"e_1_2_9_3_1","first-page":"278","article-title":"Diagnosis and management of psoriasis","volume":"63","author":"Kim WB","year":"2017","journal-title":"Can Fam 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