{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:44:25Z","timestamp":1790286265373,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2018jcyjAX0195"],"award-info":[{"award-number":["cstc2018jcyjAX0195"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a chronic inflammatory skin disease with high incidence and recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the efficacy of 30% supramolecular salicylic acid (SSA) in the treatment of acne, especially its effect on facial sebum secretion and the skin barrier.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Chemical peeling treatment with SSA using self\u2010contrast was performed every 2\u00a0weeks for a total of four treatments in 25 patients. VISIA photographs and skin parameter measurements were recorded at every treatment, with a 2\u2010week follow\u2010up after the last treatment. We performed skin biopsy and immunohistochemical staining to detect sterol response element\u2010binding proteins (SREBPs), fatty acid synthase (FAS), and cyclooxygenase 2 (COX2), which are important factors involved in the regulation of sebum metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The global acne\u2010grading system (GAGS) score of patients with acne decreased with 30% SSA treatment. The sebum level in the nose (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), chin (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), left cheek (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), and right cheek (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05) improved significantly with increasing number of treatments. The T\u2010zone sebum level (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) improved more than the U\u2010zone (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01). The VISIA index porphyrin score also reduced (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001). Skin hydration (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), transepidermal water loss (TEWL) (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05), and pH value (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.01)\u2014reflecting the skin barrier\u2014were also improved. Immunohistochemistry showed decreased expression of SREBPs, FAS, and COX2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Peels with 30%SSA effectively treated acne and reduced facial sebum secretion without damaging the skin barrier. Reduction of sebum showed cumulative effect, which suggests that multiple 30%SSA chemical peels are beneficial to acne patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14799","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T18:55:13Z","timestamp":1643050513000},"page":"3398-3405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["30% supramolecular salicylic acid peels effectively treats acne vulgaris and reduces facial sebum"],"prefix":"10.1111","volume":"21","author":[{"given":"Lingzhao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Dermatology the First Affiliated Hospital of Chongqing Medical University  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