{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T19:44:38Z","timestamp":1787600678503,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an autoimmune and acquired disease characterized by the destruction of epidermal melanocytes leading to depigmentation of the skin. Although vitiligo is a common disease, there is not a definite cure and conventional therapies can lead to serious adverse effects. Turmeric has been widely studied for its anti\u2010inflammatory, antioxidant, and anti\u2010cell proliferation, while it is a cost\u2010benefit and available treatment for a variety of diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to evaluate the efficacy of topical turmeric cream on vitiligo's lesion appearance including size and repigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Following the screening, 30 patients were enrolled according to inclusion criteria. The patients received training to apply turmeric and placebo cream at the specified side of their body twice a day for 4\u00a0months. Patients were evaluated at the baseline and at monthly intervals to access possible side effects. Lesion size, vitiligo area scoring index (VASI), vitiligo noticeability scale (VNS), and physician global assessment (PGA) were evaluated at the baseline and after four months to compare the changes induced by turmeric and placebo cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients completed the trial. Applying turmeric cream reduced the size of lesions and improved lesion's appearance significantly compared to the placebo group (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and also, patient's satisfaction score was higher following applying turmeric cream compared to placebo (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Turmeric cream can be used as an alternative remedy or adjuvant therapy in mild to moderate vitiligo lesions and in those who cannot tolerate the adverse effects of conventional therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14814","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T16:57:53Z","timestamp":1643734673000},"page":"4454-4461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Therapeutic effects of turmeric topical cream in vitiligo: A randomized, double\u2010blind, placebo\u2010controlled pilot study"],"prefix":"10.1111","volume":"21","author":[{"given":"Samin","family":"Jalalmanesh","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Medical Laser Research Centers \u2013 Academic Center for Education, Culture and Research Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4303-2892","authenticated-orcid":false,"given":"Mehdi","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Monji","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8976.1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00130.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.905340"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.09.043"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"15","article-title":"Advances in Vitiligo: an update on medical and surgical treatments","volume":"10","author":"Dillon AB","year":"2017","journal-title":"J Clin Aesthet 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