{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:32:49Z","timestamp":1747186369746,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>As an alternative to other approaches to facial rejuvenation, the air\u2010toxin technique (dermal injection of air with micro\u2010doses of botulinum toxin) is a promising method. We aimed to describe this novel technique and assess the overall safety and efficacy of the air\u2010toxin technique in facial rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective chart review was performed on cases treated with the air\u2010toxin technique. A total of 47\u00a0Korean patients underwent a single treatment session. Treatment efficacy was assessed objectively with serial VISIA<jats:sup>\u00ae<\/jats:sup> (Canfield Scientific, NJ, USA) skin analysis data and subjectively based on the patients\u2019 assessment scores at Week 12.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant improvement in wrinkle (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), UV spot (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and porphyrin (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) was objectively seen at 12\u00a0weeks follow\u2010up. Patients noted improvement in the categories wrinkle (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01), redness (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), texture (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), dilated pore (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), and lifting (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) at Week 12 compared to baseline. No major adverse event was reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show that the air\u2010toxin technique is efficacious in facial rejuvenation as shown by improved skin analysis parameters and patient assessment scores. Notably, there was some discrepancy between the objective and subjective parameters of improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14832","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T08:53:36Z","timestamp":1644051216000},"page":"1953-1958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Air\u2010toxin technique: Introduction and analysis of effect using a photoimaging system"],"prefix":"10.1111","volume":"21","author":[{"given":"Seung Hoon","family":"Kang","sequence":"first","affiliation":[{"name":"FOUR SEASONS Dermatology Clinic  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Dermatology Incheon St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-0474","authenticated-orcid":false,"given":"Hei Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Incheon St. Mary\u2019s Hospital College of Medicine The Catholic University of Korea  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14284"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13159"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001169"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12557"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12317"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.012"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.11.022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins9120403"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452341"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12433"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13944"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5616"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007248"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-020-00414-7"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2009.00467.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001827"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2016.1202418"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-004-2068-z"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002379"},{"issue":"2","key":"e_1_2_9_21_1","first-page":"34","article-title":"A single\u2010blind, split\u2010face, randomized, pilot study comparing the effects of intradermal and intramuscular injection of two commercially available botulinum toxin a formulas to reduce signs of facial aging","volume":"10","author":"Sapra P","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2018.30.4.458"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000005838"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002943"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.12204"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001170"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12037"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13370"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12866"},{"issue":"9","key":"e_1_2_9_30_1","first-page":"847","article-title":"Use of intradermal botulinum toxin to reduce sebum production and facial pore size","volume":"7","author":"Shah AR","year":"2008","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1708241"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.738914"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.06.009"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00725.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23425.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12097"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001819"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000277"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.12.004"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2014.1003238"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2021.1880598"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12561"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X10383250"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04627.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2016.1157367"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23279"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-86502014000400002"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14832","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:40:43Z","timestamp":1692661243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jocd.14832"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14832","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2022,2,14]]},"assertion":[{"value":"2021-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}