{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:24Z","timestamp":1787015544150,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acne vulgaris is a multifactorial disease that mostly heals by scarring. Interleukin\u20101 beta (IL\u20101\u03b2) is a proinflammatory cytokine, suggested to play a key role in acne pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the immunohistochemical (IHC) expression of IL1\u03b2 in acne vulgaris and acne scars to evaluate its possible role in their pathogenesis and to study the relation between the expression of IL1\u03b2 and the clinicopathological parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This study was conducted on sixty subjects (twenty patients with acne vulgaris and twenty patients with acne scars), and twenty healthy volunteers as controls. Skin biopsies were taken from patients and controls for routine histopathological examination with hematoxylin and eosin stain and IHC staining of IL\u20101\u03b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was a statistically significant increase in expression of IL\u20101\u03b2 in acne vulgaris compared with post\u2010acne scars and controls, (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) for both. IL\u20101\u03b2 expression was significantly positively correlated with both clinical severity of acne vulgaris (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022) and severity of histopathological inflammation (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Interleukin\u20101\u03b2 expression was associated with acne vulgaris and post\u2010acne scars with significant positive correlation to clinical and histopathological severity of acne vulgaris. Thus, IL\u20101\u03b2 could be a key player cytokine in acne pathogenesis, its severity and development of post\u2010acne scars.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14852","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T22:28:40Z","timestamp":1645050520000},"page":"4864-4870","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Study of interleukin\u20101 beta expression in acne vulgaris and acne scars"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-0927","authenticated-orcid":false,"given":"Yasmina","family":"ElAttar","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basma","family":"Mourad","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hebat\u2010Allah","family":"Alngomy","sequence":"additional","affiliation":[{"name":"Mansoura Hospital for Dermatology &amp; Leprology  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliaa","family":"Shams El Deen","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Tanta University  Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6273-5174","authenticated-orcid":false,"given":"Mayada","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Faculty of Medicine Tanta University  Tanta 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