{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:01:00Z","timestamp":1775743260337,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus is a series of autoimmune skin disorders caused by IgG. Regulatory T cells (Tregs) are a subset of CD4+ T cells that mostly block pathogenic immune responses mediated by self\u2010reactive cells; therefore, a lack of Tregs or a malfunction in their activity could lead to a loss of tolerance and the development of autoimmunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the expression of lesional and perilesional Treg markers (CD<jats:sub>4<\/jats:sub><jats:sup>+<\/jats:sup> CD<jats:sub>25<\/jats:sub><jats:sup>+<\/jats:sup> bright FOXP<jats:sub>3<\/jats:sub><jats:sup>+<\/jats:sup>) in pemphigus patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Twenty\u2010three pemphigus patients and 20 healthy controls were included in this study. The expression of CD<jats:sub>4<\/jats:sub>, CD<jats:sub>25,<\/jats:sub> and Foxp<jats:sub>3<\/jats:sub> was evaluated by immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was statistically significant increase in CD4+ T lymphocytes in lesional skin of pemphigus compared to perilesional skin and control group (<jats:italic>p<\/jats:italic>\u2010value: 0.001). There was statistically significant decrease in CD25<jats:sup>+<\/jats:sup> and Foxp3<jats:sup>+<\/jats:sup> cells in lesional skin compared to perilesional and control group (<jats:italic>p<\/jats:italic>\u2010value: &lt;0.001, 0.025, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The reduction of lesional skin Tregs may play an important role in the pemphigus pathogenesis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14854","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T03:45:03Z","timestamp":1645069503000},"page":"4871-4876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Immunohistochemical expression of regulatory T cells (CD<sub>4<\/sub><sup>+<\/sup> CD<sub>25<\/sub><sup>+<\/sup> bright FOXP<sub>3<\/sub><sup>+<\/sup>) in pemphigus patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-1967","authenticated-orcid":false,"given":"Wafaa Mohamed","family":"Abd El\u2010Magid","sequence":"first","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Venereology, and Andrology Sohag University  Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheren FM","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Pathology Sohag University  Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanan","family":"Assaf","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Venereology, and Andrology Sohag University  Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reham Ebraheem","family":"Abd Elkhalek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology Sohag Educational Hospital  Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Department of Dermatology, Venereology, and Andrology Sohag University  Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"issue":"11","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1111\/ddg.13688","article-title":"Bullous autoimmune dermatoses","volume":"16","author":"Hofmann SC","year":"2018","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2706"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/jomfp.JOMFP_79_17"},{"issue":"10","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1610-0387.2011.07793.x","article-title":"Autoimmune bullous skin diseases. 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