{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:48:22Z","timestamp":1756385302286,"version":"3.41.0"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T00:00:00Z","timestamp":1645574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Lipoid proteinosis (LP) or Hyalinosis Cutis et Mucosae or Urbach\u2013Wiethe disease is a rare autosomal recessive genodermatosis characterized by an amorphous hyaline material deposition in the skin mucosa and viscera. The clinical symptoms of this disease often begin in childhood, which persist throughout life. Skin manifestations include inflammation, scaling, acne, and eventually ulceration, and hyaline amorphous deposits in these areas of the wound cause a waxy and thick appearance on the skin. In addition, wounds leave atrophic scars like chickenpox.<\/jats:p><\/jats:sec>Aim<\/jats:title>Herein, we present the first case of LP in the north of Iran; although LP is a sporadic disease, it occurs all around the world, with about 400 cases worldwide having been reported thus far.<\/jats:p><\/jats:sec>Patient<\/jats:title>We report the case of a 28\u2010year\u2010old female patient with a history of skin lesions on her face, scalp, extremities, and buttock, as well as hoarse cry, respiratory problems, dysphagia, and migraine since childhood. There was no evidence of other clinical presentations. A biopsy was taken from the lesions, and the patient was diagnosed with LP. A laryngeal laser was performed for the patient, and peeling creams were used for her skin lesions.<\/jats:p><\/jats:sec>Result<\/jats:title>According to previous findings, there has been no case report of LP with systemic symptoms in the north of Iran.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14861","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T17:34:22Z","timestamp":1645119262000},"page":"4237-4240","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lipoid proteinosis: A systematic presentation of an unusual disease"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-792X","authenticated-orcid":false,"given":"Ramin","family":"Mofarrah","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Islamic Azad University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Immunogenetics Research Center Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramina","family":"Mofarrah","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadaf","family":"Emadi","sequence":"additional","affiliation":[{"name":"Student Research Committee Islamic Azad University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Rostamian","sequence":"additional","affiliation":[{"name":"Student Research Committee Islamic Azad University of Medical Sciences Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2014.1168"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100625.2007.00608.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/324506"},{"issue":"3","key":"e_1_2_8_5_1","first-page":"162","article-title":"Lipoid proteinosis: case report and review of the literature","volume":"26","author":"Di Giandomenico S","year":"2006","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"11","key":"e_1_2_8_6_1","first-page":"767","article-title":"Otolaryngological manifestations and genetic characteristics of lipoid proteinosis","volume":"119","author":"Xu W","year":"2010","journal-title":"Ann Otol Rhinol 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