{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:23:28Z","timestamp":1789068208206,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007289","name":"Nanjing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was performed to analyze the efficacy, adverse reactions of fractional CO<jats:sub>2<\/jats:sub>\u00a0laser for atrophic acne scars, and related clinical factors. Methods: The clinical data of 121 patients with atrophic acne scars treated with ultra\u2010pulsed fractional CO<jats:sub>2<\/jats:sub>\u00a0laser in the Cosmetic Dermatology from August 2014 to March 2020 were retrospectively analyzed. The efficacy and adverse reactions of atrophic acne scar after fractional CO<jats:sub>2<\/jats:sub>\u00a0laser therapy were statistically analyzed. The clinical factors related to efficacy and adverse reactions after the first therapy session were analyzed by multivariate logistic regression. Results: A total of 121 patients received 206\u00a0sessions of fractional CO<jats:sub>2<\/jats:sub>\u00a0laser therapy, with an average of 1.7\u00a0sessions. Moderate to excellent improvement rate reached 50.4% after the first session. Multivariate logistic regression analysis indicated that rolling scars responded better to fractional CO<jats:sub>2<\/jats:sub>\u00a0laser treatment than icepick scars (OR\u00a0=\u00a07.3, 95% CI [1.2, 43.4], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.029), and scar improvement was more significant in the high\u2010energy laser group than in the low\u2010energy laser group (OR\u00a0=\u00a010.9, 95% CI [1.1, 106.8], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.041). The main adverse reactions after fractional laser surgery were pigmentation, skin sensitivity, persistent erythema, and acneiform eruption. Multivariate logistic analysis revealed that the longer the scar duration, the higher incidence of postoperative adverse reactions (OR\u00a0=\u00a01.3, 95% CI [1.1, 1.5], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). Compared with icepick scars, rolling scars (OR\u00a0=\u00a010.4, 95% CI [2.3, 47.7], <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003) and boxcar scars (OR\u00a0=\u00a012.0, 95% CI [3.3, 44.0], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) had higher risk of developing adverse reactions. The incidence of postoperative adverse reactions was also higher in the combined mode group (DeepFX mode\u00a0+\u00a0ActiveFX mode) than in the single\u2010mode group (OR\u00a0=\u00a07.8, 95% CI [2.4, 25.5], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Conclusion: Fractional CO<jats:sub>2<\/jats:sub> laser was effective in the treatment of atrophic acne scars, without serious adverse reactions. Scar type and laser energy were independent clinical factors affecting its efficacy. Scar course, scar type, and fractional laser mode were independent clinical factors affecting its adverse reactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14868","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T06:43:20Z","timestamp":1645253000000},"page":"1989-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy and adverse reactions of fractional CO<sub>2<\/sub> laser for atrophic acne scars and related clinical factors: A retrospective study on 121 patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Bingyan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of cosmetic dermatology Friendship Plastic Surgery Hospital Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehui","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8156-9087","authenticated-orcid":false,"given":"Xufeng","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"She","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingrong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0358-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2015.11.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.02.040"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14539"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.DSS.0000452625.01889.c3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.15171\/jlms.2018.08"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001219"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2013.854639"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2010.01803.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329415"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14432"},{"key":"e_1_2_8_13_1","unstructured":"SharmaAN PatelBC.Laser Fitzpatrick Skin Type Recommendations. In: StatPearls. edn. Treasure Island (FL);2021."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23369"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.138326"},{"issue":"6","key":"e_1_2_8_16_1","first-page":"51","article-title":"Nonablative fractional laser resurfacing in skin of color: evidence\u2010based review","volume":"10","author":"Kaushik SB","year":"2017","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14764172.2018.1461230"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12981"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13514"},{"key":"e_1_2_8_20_1","first-page":"CD011946","article-title":"Interventions for acne scars","volume":"4","author":"Abdel Hay R","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_21_1","unstructured":"YumeenS KhanT.Laser Carbon Dioxide Resurfacing. In: StatPearls. edn. Treasure Island (FL);2021."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.21061"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13426"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14868","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14868","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14868","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:42:36Z","timestamp":1692661356000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,25]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jocd.14868"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14868","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,25]]},"assertion":[{"value":"2021-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}