{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:48:32Z","timestamp":1773996512919,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is a lack of published data investigating injection of autologous platelet rich plasma (A\u2010PRP) alone in the treatment of postmenopausal VVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this pilot study, we aimed to investigate the safety and efficacy of injection of A\u2010PRP alone in postmenopausal VVA in women without the history of cancer breast to explore its utility as a hormone free therapy for postmenopausal VVA and for vulvovaginal rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this pilot study, 47 women with postmenopausal VVA were included. Vulvovaginal condition was evaluated at the baseline by vaginal health index (VHI). Impact of VVA on quality of life and sexual life was evaluated at the baseline by vulvovaginal symptom questionnaire (VSQ). Treatment protocol was 2\u00a0sessions of A\u2010PRP injection with 1\u00a0month interval. Response was evaluated 1\u00a0month after the last session by VHI and VSQ. Side effects were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postmenopausal VVA was significantly improved by A\u2010PRP injection as indicated by significant improvement of total VHI score and its items at 1\u00a0month post\u2010treatment (<jats:italic>p<\/jats:italic> value &lt;0.001). Moreover, there was significant improvement of burning, hurting, being irritated, being dry, discharge, desire to be intimate, sexual relationships, pain during sexual activity, and dryness during sexual activity at 1\u00a0month post\u2010treatment as indicated by VSQ (<jats:italic>p<\/jats:italic> value =0.045 for being dry and &lt;0.001 for other items).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Autologous platelet rich plasma injection is safe and effective as minimally invasive monotherapy for postmenopausal VVA without history of cancer breast and hence for vulvovaginal rejuvenation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14873","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T08:39:44Z","timestamp":1645605584000},"page":"4269-4275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical evaluation of autologous platelet rich plasma injection in postmenopausal vulvovaginal atrophy: A pilot study"],"prefix":"10.1111","volume":"21","author":[{"given":"Doaa M.","family":"Saleh","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"},{"name":"Armed Forces College of Medicine (AFCM)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-8375","authenticated-orcid":false,"given":"Rania","family":"Abdelghani","sequence":"additional","affiliation":[{"name":"Armed Forces College of Medicine (AFCM)  Cairo Egypt"},{"name":"Dermatology and Venereology Faculty of Medicine for Girls Al\u2010Azhar University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2005.06.014"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(03)00676-9"},{"key":"e_1_2_9_4_1","first-page":"9","article-title":"Vaginal pH, estrogen and genital atrophy","volume":"17","author":"Freedman 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