{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T14:10:11Z","timestamp":1748355011683,"version":"3.41.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gynoid lipodystrophy is one of the most common cosmetical problems in women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study aims to examine the pathomorphology and histology of subcutaneous tissue in women with gynoid lipodystrophy exposed to local compression\/vibration therapy using a non\u2010invasive Beautylizer Therapy Cosmospheres V medical device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study enrolled 25 virtually healthy women aged 25\u201345\u00a0years with gynoid lipodystrophy grades I and II. The women included in the study completed a 10\u2010session month\u2010long therapeutic course with a non\u2010invasive Beautylizer Therapy Cosmospheres V medical device. Bioptic punch\u2010size samples were taken from the gluteal region prior to and following the 10\u2010session therapy course with the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After completing a 10\u2010session treatment course, a decrease in the mean adipocyte area from 123.08\u00a0\u00b1\u00a013.60\u00a0\u03bcm to 67.14\u00a0\u00b1\u00a04.20\u00a0\u03bcm was observed in punch bioptic samples of subcutaneous fat tissues of women with gynoid lipodystrophy as compared with the pre\u2010treatment indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thus, local application of 10\u2010session therapy with a non\u2010invasive Beautylizer Therapy Cosmospheres V medical device in women with gynoid lipodystrophy demonstrated a positive effect on the histological structure of the hypodermis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14874","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T09:32:14Z","timestamp":1645695134000},"page":"4631-4636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of combined compression\u2010vibration therapy using non\u2010invasive Beautylizer Therapy Cosmospheres V on the subcutaneous tissue morphology in women with gynoid lipodystrophy (pilot study)"],"prefix":"10.1111","volume":"21","author":[{"given":"Svetlana","family":"Pervykh","sequence":"first","affiliation":[{"name":"DocMed Clinic of Evidence\u2010Based Medicine  Moscow Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalya","family":"Bychkova","sequence":"additional","affiliation":[{"name":"Federal State Budget\u2010Funded Educational Institution of Higher Education \u201cIzhevsk State Medical Academy\u201d of the Ministry of Health of Russia (FGBOU VO IGMA of the MoH of Russia)  Izhevsk Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S95830"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000002388"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.12968\/joan.2021.10.8.352"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2018.77235"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjy274"},{"key":"e_1_2_9_7_1","first-page":"907","article-title":"Lipodystrophy: a paradigm for understanding the consequences of \u201coverloading\u201d adipose tissue","volume":"101","author":"Lim K","year":"2020","journal-title":"Physiol Rev"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118661932.ch5"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-27814-3_160-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2018.09.002"},{"issue":"9","key":"e_1_2_9_11_1","first-page":"1765","article-title":"Causes of lipodystrophy","volume":"8","author":"Korabiusz K","year":"2018","journal-title":"J Educ Health Sport"},{"issue":"3","key":"e_1_2_9_12_1","first-page":"77","article-title":"The nodule of discord: the unresolved diatribe on the pathogenesis of cellulite in the light of the ad\u2010ipocyte pathophysiology","volume":"1","author":"Terranova F","year":"2015","journal-title":"Aesthet Med"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2018.05.008"},{"key":"e_1_2_9_14_1","first-page":"98","article-title":"Physiophatology of gynoid lipodystrophy","volume":"7","author":"Cunha MG","year":"2015","journal-title":"Surg Cosmet Dermatology"},{"issue":"3","key":"e_1_2_9_15_1","first-page":"40","article-title":"Morphological description of hypothetical cellulite starting unit. 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