{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T14:10:12Z","timestamp":1748355012113,"version":"3.41.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Female pattern hair loss (FPHL) is a common dermatological complaint with multifactorial etiology. Nuclear factor erythroid\u20102\u2010related factor 2 (NRF2) is a transcription factor that has a major role in protection from ROS\u2010induced apoptosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the relationship between Nrf2 and systemic oxidative stress in FPHL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This case\u2013control study included 30 patients with FPHL and 30 age\u2010 and sex\u2010matched healthy volunteers as a control group. Serum NRF2, total antioxidant capacity (TAC), and total oxidant capacity (TOC) were measured by ELISA, and oxidative stress index (OSI) was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum level of TOC and OSI was found to be significantly higher (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.001 for both) while serum level of NRF2 and TAC was found to be significantly lower in cases than controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001 for both). There were a significant negative correlation between TAC and BMI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.03, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.391) and a significant positive correlation between OSI and BMI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.365). There were a significant positive correlation between serum level of NRF2 and TAC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003, <jats:italic>r<\/jats:italic>\u00a0=\u00a00.532) and a significant negative correlation between serum the level of NRF2 and TOC (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.418) and OSI (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.003, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.395).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Systemic oxidative stress in FPHL may be, at least in part, due to NRF2 deficiency. NRF2 activators may help in treatment of this disease. NRF2 deficiency has no role in disease severity. Healthy diet and body weight reduction may help in improving oxidative stress and subsequently improving FPHL.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14878","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T16:21:39Z","timestamp":1645719699000},"page":"4882-4887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Serum nuclear factor E\u20102\u2010related factor 2 in female pattern hair loss"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0319-4480","authenticated-orcid":false,"given":"Ola A.","family":"Bakry","sequence":"first","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine Menoufiya University  Shibeen El Koom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Sobhy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology Menoufiya University  Shibeen El Koom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Essam El Deen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine Menoufiya University  Shibeen El Koom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Seleit","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Andrology and STDs Faculty of Medicine Menoufiya University  Shibeen El Koom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14055"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12341"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09661.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3920\/978-90-8686-728-8_5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.15378"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00479-x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153370"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/767628"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb15179.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.117426"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.58555"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.10.014"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v32i5.6920"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.02.012"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.08.035"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijwd.2017.11.007"},{"key":"e_1_2_7_19_1","unstructured":"AbdullahA.Assessment of Human Nuclear Factor Erythroid 2 Related Factor 2 (NRF2) in Androgenetic Alopecia in Egyptian Men. 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