{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:32:55Z","timestamp":1747186375418,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Facial aging is a complex process, which, beyond a genetic predisposition, involves both physical and environmental factors. Even identical twins with the same genetic load may differ substantially in facial wrinkles and aging, demanding a personalized treatment approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To demonstrate the ONE21 technique as an excellent tool to a customized assessment and IncobotulinuntoxinA treatment to address phenotype discordances and epigenetic drifts in identical twins, expressed by different patterns of upper face muscle contractions and wrinkles intensity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Five pairs of identical Caucasian twin sisters, from 30 to 45\u00a0years of age, were evaluated for hyperfunctional upper facial wrinkles (forehead, glabella, and periorbital), assessing the individual anatomy, muscle function and habitual facial movements of each patient. All the subjects were treated with the ONE21 technique using IncobotulinumtoxinA and reevaluated 30\u00a0days after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Though the clinical\u2010anatomical pattern of the forehead contraction was similar between the pairs, the strength of the muscles, the number and depth of wrinkles differed. This varied presentation demanded distinct points of distribution and dosages of incobotulinumtoxinA for all the twins, according to the ONE21 approach. The results 30\u00a0days after treatment were satisfactory in all the subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ONE21 technique allows an objective and careful evaluation of the wrinkles of the upper face, based on an individualized assessment, which may vary even in identical twins.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14879","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T16:21:42Z","timestamp":1645719702000},"page":"1940-1947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["ONE21 technique for an individualized assessment and treatment of upper face wrinkles in five pairs of identical twins with IncobotulinumtoxinA"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0711-281X","authenticated-orcid":false,"given":"Carla","family":"de Sanctis Pecora","sequence":"first","affiliation":[{"name":"Dermatologie, Cl\u00ednica Cirurgia e Laser  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Ventura Ferreira","sequence":"additional","affiliation":[{"name":"Dermatologie, Cl\u00ednica Cirurgia e Laser  S\u00e3o Paulo\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"H\u00e9lio","family":"Amante Miot","sequence":"additional","affiliation":[{"name":"Departamento de Dermatologia da FMB\u2010Unesp  Botucatu\u2010SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"846","article-title":"First consensus on primary prevention and early intervention in aesthetic medicine","volume":"16","author":"Landau M","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000475758.63709.23"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S237519"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2009.303"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504743102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S281901"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000082192.45787.B6"},{"key":"e_1_2_11_9_1","first-page":"297","article-title":"IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus recommendations","volume":"8","author":"Yutskovskaya Y","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-5361-8_3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/1677-5449.210038"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861774"},{"key":"e_1_2_11_13_1","first-page":"471","article-title":"Understanding the shape of forehead lines","volume":"16","author":"Moqadam M","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_14_1","first-page":"1041","article-title":"Consideration of muscle mass in glabellar line treatment with botulinum toxin type A","volume":"11","author":"Monheit G","year":"2012","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000006756"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13875"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500398102"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.12.011"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2019.11.038"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.5617"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14879","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14879","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:43:51Z","timestamp":1692661431000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,14]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jocd.14879"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14879","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2022,3,14]]},"assertion":[{"value":"2021-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}