{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:01:02Z","timestamp":1780084862116,"version":"3.54.0"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Telogen effluvium (TE) is one of the causes of non\u2010scarring hair loss that occurred commonly 2\u20133\u00a0months after a triggering factor. It was reported that the incidence of TE increased during the COVID\u201019 (coronavirus disease 2019) pandemic. However, to date, there is no study evaluating the status of COVID\u201019 before the onset of hair loss in patients with TE. The aim of this study is to evaluate the patients with TE whether they had COVID\u201019 or not before the onset of their hair loss and to compare the demographic and clinical characteristics and laboratory parameters of those with and without a history of COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted an observational cohort study of TE patients. The diagnosis of TE depended on anamnesis and physical examination of the patients. Also, hair pull test was performed. Demographic data and the results of COVID\u201019 real\u2010time polymerase chain reaction (RT\u2010PCR) were recorded from the electronic medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 181 patients with TE were included in the study. Sixty\u2010four of patients (35.4%) had been diagnosed with COVID\u201019 before the hair loss started. The median duration of development of hair loss was 2\u00a0months (range 1\u201311\u00a0months, IQR 3) after COVID\u201019 diagnosis. In this group, 87.5% of patients (<jats:italic>n\u00a0=<\/jats:italic>\u00a056) had acute TE and 12.5% of patients (<jats:italic>n\u00a0=<\/jats:italic>\u00a08) had chronic TE. The rate of acute TE and the use of vitamin supplements were ignificantly higher (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001 and <jats:italic>p<\/jats:italic>\u00a0=\u00a00.027, respectively) and the monocyte count in peripheral blood was lower (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041) in the group diagnosed with COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and Conclusion<\/jats:title><jats:p>It was stated that monocytes and macrophages infected by SARS\u2010CoV\u20102 can produce pro\u2010inflammatory cytokines that play a crucial role in the development of COVID\u201019\u2010related complications. Also, it was suggested that the number of monocytes tends to be lower in the late recovery stage. The lower monocyte count in patients with a history of COVID\u201019 in our study may be related to evaluating the patients in the late period of recovery and the migration of circulating monocytes to hair follicles. The history of COVID\u201019\u00a0must be questioned in patients with TE. It should be kept in mind that hair loss that develops after COVID\u201019\u00a0may be presented as chronic TE form too. The exact mechanisms of hair loss induced by COVID\u201019 are not fully explained; the roles of monocytes on the hair follicles may be one of the responsible mechanisms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14883","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T16:43:32Z","timestamp":1645721012000},"page":"1809-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of patients with telogen effluvium during the pandemic: May the monocytes be responsible for post COVID\u201019 telogen effluvium?"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0633-1770","authenticated-orcid":false,"given":"Sema","family":"Ko\u00e7 Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology U\u015fak University Training and Research Hospital  U\u015fak 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257\u2010020\u201000558\u20104"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2020.11.032"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.14096"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2021.03.099"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11845\u2010021\u201002754\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517223"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.14761"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JAAD.2021.07.021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/JDV.17045"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.15175"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7759\/CUREUS.8320"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/OFID\/OFAA507"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JDIN.2021.07.006"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/DTH.14547"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ABD.2021.05.006"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3949\/CCJM.87A.CCC046"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/NU12092550"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/EXD.14352"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/JIR.1997.17.151"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1796425"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.LFS.2020.118102"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/2058738420966497"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/CID\/CIAA248"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.13.20100925"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106504"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.AJEM.2020.11.058"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/S40801\u2010015\u20100056\u2010Z\/TABLES\/2"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CMI.2020.09.023"}],"container-title":["Journal 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