{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:27:54Z","timestamp":1789676874271,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to develop a prototype skincare product with bee venom, propolis, honey, beeswax, and royal jelly. The prototype formulation contained 0.1% bee venom, 0.3% propolis extract, 0.45% honey, and 1.0% royal jelly. The prototype body cream was analyzed for stability, antioxidant activity, dermatological response, and cytotoxicity. In addition, a panel test evaluated the prototype for the claims such as skin smoothness, feelings of nourishment, moisturizing, skin tone, brightness, and visibility of wrinkles. According to the stability test, the prototype was stable for up to 90\u00a0days at room temperature and +40\u00b0C. The formulation was found to have a high antioxidant capacity at 85.45%. Cell viability detected over 70% indicated that the prototype body cream was not cytotoxic. The dermatological analysis revealed no irritation or allergic reaction in non\u2010allergic individuals. Panel test showed that the prototype makes skin silky smooth, contributes to hydration, brightens and nourishes the skin, evens the skin tone, reduces the visibility of wrinkles, improves skin elasticity, and smoothes wrinkles. This prototype formulation requires further research to evaluate its effectiveness against skin aging on different skin types. Nevertheless, the side effects of such products need particular attention in developing a commercial product containing bee venom in susceptible individuals.<\/jats:p>","DOI":"10.1111\/jocd.14891","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T07:48:17Z","timestamp":1646293697000},"page":"4913-4920","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Development of a cream formulation containing bee venom and other bee products"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1639-6495","authenticated-orcid":false,"given":"Asl\u0131 Elif","family":"Tanu\u011fur Samanc\u0131","sequence":"first","affiliation":[{"name":"Department of Biology D\u00fczce University  D\u00fczce Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meral","family":"Keke\u00e7o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Biology D\u00fczce University  D\u00fczce Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Farmakoloji Ders Kitab\u0131","author":"S\u00fczer P\u00d6","year":"2008"},{"key":"e_1_2_9_3_1","volume-title":"Value\u2010Added Products from Beekeeping","author":"Krell R","year":"1996"},{"key":"e_1_2_9_4_1","first-page":"927","volume-title":"The Hive and the Honey Bee","author":"Schmidt JO","year":"1992"},{"key":"e_1_2_9_5_1","unstructured":"Tekeo\u011flu\u0130 Akdo\u011fanM.\u201cBal Ar\u0131s\u0131 Zehirinin Tamamlay\u0131c\u0131 T\u0131ptaki G\u00fcncel Yeri\u201d Ankara Akupunktur ve Tamamlay\u0131c\u0131 T\u0131p Dergisi.2016. 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