{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:49:11Z","timestamp":1792090151218,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral finasteride is an FDA\u2010approved treatment for androgenetic alopecia (AGA). Topical finasteride, while not FDA\u2010approved, lacks the systemic adverse effects associated with oral finasteride. The efficacy of topical finasteride has been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review whether topical finasteride is a safe and effective treatment for male and female pattern hair loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A structured search in PubMed and Google Scholar identified 864 records, with 32 articles meeting the inclusion criteria for review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and discussion<\/jats:title><jats:p>In a phase III, randomized, controlled trial, the efficacies of topical 0.25% w\/w finasteride spray (1\u20134 sprays; 50\u2013200\u00a0\u03bcl\/day) and once\u2010daily finasteride 1 mg oral tablet were similar when administered for 24\u00a0weeks (mean change from baseline, 20.2 vs. 21.1 hairs\/cm<jats:sup>2<\/jats:sup>). Additionally, a double\u2010blind, randomized trial compared the efficacies of twice\u2010daily finasteride 1% topical gel and once\u2010daily finasteride 1 mg oral tablet for 6\u00a0months, and found similar results in both groups. Moreover, a combination of topical minoxidil and topical finasteride may enhance efficacy.<\/jats:p><jats:p>Topical finasteride reduces both scalp and plasma DHT levels. In an open\u2010label pharmacodynamic study, a 7\u2010day treatment of twice\u2010daily finasteride 0.25% topical solution and once\u2010daily finasteride 1 mg oral tablet provided similar inhibition of plasma DHT.<\/jats:p><jats:p>Topical finasteride reduces the potential for systemic side effects, including the risk of sexual dysfunction. The side effects are localized to the application site, for example, scalp pruritus, burning sensation, irritation, contact dermatitis, and erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical finasteride may be an alternative for those concerned about the oral formulation's systemic side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14895","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T08:28:41Z","timestamp":1646296121000},"page":"1841-1848","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Topical finasteride for male and female pattern hair loss: Is it a safe and effective alternative?"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8664-7723","authenticated-orcid":false,"given":"Aditya K.","family":"Gupta","sequence":"first","affiliation":[{"name":"Mediprobe Research Inc.  London ON Canada"},{"name":"Division of Dermatology, Department of Medicine University of Toronto  Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesbah","family":"Talukder","sequence":"additional","affiliation":[{"name":"Mediprobe Research Inc.  London ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.07.001"},{"key":"e_1_2_13_3_1","first-page":"38","volume-title":"Hair Transplantation","author":"Rogers NE"},{"key":"e_1_2_13_4_1","first-page":"1","article-title":"Minoxidil: a comprehensive review","author":"Gupta AK","year":"2021","journal-title":"J Dermatolog Treat"},{"key":"e_1_2_13_5_1","first-page":"1","article-title":"Finasteride for hair loss: a review","author":"Gupta AK","year":"2021","journal-title":"J Dermatol Treat"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17738"},{"issue":"1","key":"e_1_2_13_7_1","first-page":"38","article-title":"Long\u2010term (5\u2010year) multinational experience with finasteride 1 mg in the treatment of men with androgenetic alopecia","volume":"12","author":"Finasteride Male Pattern Hair Loss Study Group","year":"2002","journal-title":"Eur J Dermatol"},{"issue":"4","key":"e_1_2_13_8_1","first-page":"400","article-title":"Long\u2010term treatment with finasteride 1 mg decreases the likelihood of developing further visible hair loss in men with androgenetic alopecia (male pattern hair loss)","volume":"18","author":"Kaufman KD","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2011.01441.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14719"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.15761\/CRT.1000273"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sxmr.2018.07.003"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14728"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14223"},{"issue":"7","key":"e_1_2_13_15_1","first-page":"56","article-title":"Adverse effects and safety of 5\u2010alpha reductase inhibitors (finasteride, dutasteride): a systematic review","volume":"9","author":"Hirshburg JM","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2017.0089"},{"issue":"4","key":"e_1_2_13_17_1","first-page":"457","article-title":"A systematic review of topical finasteride in the treatment of androgenetic alopecia in men and women","volume":"17","author":"Lee SW","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202119"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01528"},{"key":"e_1_2_13_20_1","unstructured":"PROPECIA\u00ae (finasteride) tablets for oral use (FDA label) 2019.https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2021\/020788s028lbl.pdf. 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