{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:23:35Z","timestamp":1791894215852,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T00:00:00Z","timestamp":1647216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Segmental vitiligo (SV) is a distinctive variant of vitiligo that is usually resistant to traditional treatments. Therefore, surgical therapies are mainstay of treatment in this type of vitiligo. To date, there is no review article or systematic review that evaluates specifically efficacy of treatment modalities on SV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate current evidence regarding efficacy and safety of traditional and surgical treatment modalities in SV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a search in PubMed, Embase, Web of science, and Google Scholar for key words of \"vitiligo\" AND \"segmental\" AND \"treatment\" OR \"therapy\" OR \"surgical treatments\" OR \"medical treatments\" OR \"laser\" OR \"phototherapy\". Inclusion criteria were English literature that investigated efficacy of different treatments on three or more cases on SV from January 2000 until July 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of thirty\u2010four articles were selected for detailed assessment. Different treatment modalities include medical treatment [systemic corticosteroid (SCS), topical CS (TCS), and topical calcineurin inhibitors (TCI)], phototherapy [narrow band\u2010ultraviolet B (NB\u2010UVB), psoralen and UVA (PUVA) and psoralen+solar exposure (PUVASOL)], laser\/lights [helium\u2010neon and Excimer laser\/light (EL)] and surgical treatments [punch graft (PG), follicular graft, suction blister epidermal grafting (SBEG), spilt\u2010thickness skin graft (STSG), and cultured\/non\u2010cultured\u2010melanocytes\u2010keratinocytes transplantation (MKTP)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were few randomized controlled trials (RCT) evaluating the efficacy of treatments in SV. Therefore, future high quality studies are required for better assessment of various treatment modalities in SV. Results of current evidence indicate resistance of SV to traditional therapies unless in patients with short duration of vitiligo. Therefore, surgical interventions are the first\u2010line of treatment in refractory cases, long\u2010standing disease, or presence of leukotrichia in depigmented patches.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14899","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:59:38Z","timestamp":1646639978000},"page":"2360-2373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and safety of traditional and surgical treatment modalities in segmental vitiligo: A review article"],"prefix":"10.1111","volume":"21","author":[{"given":"Maryam","family":"Khalili","sequence":"first","affiliation":[{"name":"Department of Dermatology Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezvan","family":"Amiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Afzalipour Faculty of Medicine Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saman","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Afzalipour Faculty of Medicine Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Iranmanesh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Afzalipour Faculty of Medicine Afzalipour Hospital Kerman University of Medical Sciences  Kerman Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-8682","authenticated-orcid":false,"given":"Mahin","family":"Aflatoonian","sequence":"additional","affiliation":[{"name":"Department of Dermatology Afzalipour Faculty of Medicine Afzalipour Hospital Kerman University of Medical Sciences  Kerman 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