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So far, it has achieved some exciting progression in pattern hair loss (PHL), which bothers plenty of people and has cost billion dollars searching for more effective treatment. The aim of this study is to summarize the efficacy of mesotherapy treating PHL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, and Web of Science were searched until January 2021. All literature was evaluated according to established criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We got 336\u00a0studies from searched databases, and 12\u00a0studies were included after selection process. A total of 253\u00a0males and 274 females participated in 6 randomized control trials, 2 nonrandomized controlled trials, and 3 observational studies. Mesotherapy showed positive efficacy in all studies to a certain extent, and no significant side effect occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mesotherapy demonstrated as an effective treatment for PHL. However, the sample size is not big enough, and studies about mesotherapy compared to other treatments are insufficient. Future research is required to claim more evidence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14900","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:59:13Z","timestamp":1646639953000},"page":"4184-4193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Current application of mesotherapy in pattern hair loss: A\u00a0systematic review"],"prefix":"10.1111","volume":"21","author":[{"given":"Ziyuan","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nan Fang Hospital of Southern Medical University  Guangzhou Guangdong Province China"},{"name":"Department of Anesthesiology , Zhujiang Hospital of Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Hu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Technology  Zhuhai Guangdong Province China"},{"name":"Pace University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nan Fang Hospital of Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nan Fang Hospital of Southern Medical University  Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Plastic and Aesthetic Surgery Nan Fang Hospital of Southern Medical University  Guangzhou Guangdong Province 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