{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T18:27:10Z","timestamp":1781548030645,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Hirsutism is associated with other androgen\u2010dependent signs\/symptoms. This study was designed with the aim of a comprehensive investigation of laboratory and ultrasonographic findings in hirsute women and their probable association with the \u201cseverity\u201d of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This cross\u2010sectional study included 123 hirsute women. Comprehensive medical history of each patient was recorded, and a broad physical examination was performed by a single dermatologist. Ferriman\u2013Gallwey score was used to evaluate the hirsutism severity. Pelvic ultrasonography was done by a single radiologist for each patient, and serum levels of the follicular stimulating hormone (FSH), luteinizing hormone (LH), LH\/FSH ratio, prolactin, thyroid\u2010stimulating hormone, total testosterone, dehydroepiandrosterone sulfate, 17\u2010alpha\u2010hydroxyprogesterone, and cortisol were measured. The association of hirsutism severity and these paraclinical parameters was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A statistically significant association was observed between polycystic ovary disease (PCOD) and the severity of hirsutism. A past medical history of PCOD was found to cause more severe forms of hirsutism in the involved patients as well. The presence of hormonal abnormalities was also significantly associated with the severity of hirsutism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>More than half of the hirsute patients have endocrine abnormalities and\/or PCOD. These two disorders are associated with the severity of hirsutism.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14901","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T13:11:09Z","timestamp":1646658669000},"page":"4927-4930","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Which laboratory\/ultrasonographic parameters affect the severity of hirsutism?"],"prefix":"10.1111","volume":"21","author":[{"given":"Hoda","family":"Rahimi","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Kashi","sequence":"additional","affiliation":[{"name":"Tabnak Imaging Center  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2510-7579","authenticated-orcid":false,"given":"Zohreh","family":"Tehranchinia","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Sharifan","sequence":"additional","affiliation":[{"name":"Health Metrics Research Center Iranian Institute for Health Sciences Research ACECR  Tehran 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