{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T03:10:03Z","timestamp":1770520203484,"version":"3.49.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Submental fat (SMF) detracts from facial aesthetics and negatively impacts self\u2010image.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate safety, effectiveness, and satisfaction of cryolipolysis and ATX\u2010101 used sequentially to reduce SMF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, open\u2010label, interventional, single\u2010site study enrolling 22\u2010 to 65\u2010year\u2010old participants rated as Grade 4 (extreme) on the Clinician\u2010Rated SMF Rating Scale (CR\u2010SMFRS). Co\u2010primary effectiveness endpoints were proportions of participants with \u22651\u2010grade and \u22652\u2010grade improvement on CR\u2010SMFRS at 12\u00a0weeks post final treatment. Additional assessments included ultrasound measurement of fat thickness and Subject Self\u2010Rating Scale (SSRS) scores at 12\u00a0weeks post final treatment. Safety was assessed throughout the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 16 enrolled participants, 62.5% were female, mean age of 43, and mean body mass index of 31.8\u00a0kg\/m<jats:sup>2<\/jats:sup>. 100% of participants achieved \u22651\u2010grade improvement, and 71.4% achieved \u22652\u2010grade CR\u2010SMFRS improvement. Mean (SD) reduction in SMF thickness was 0.2\u00a0mm (1.3), and SSRS scores \u22654 (slightly to extremely satisfied) were reported by 71.4% of participants. Adverse events (AEs) were mild and resolved by study end. No unanticipated adverse device effects or serious or unexpected AEs occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sequential treatment with cryolipolysis and ATX\u2010101 was found safe and effective for reducing extreme SMF, resulting in approximately a 2\u2010grade improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14909","type":"journal-article","created":{"date-parts":[[2022,3,12]],"date-time":"2022-03-12T15:59:49Z","timestamp":1647100789000},"page":"2437-2444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Submental fat reduction using sequential treatment approach with cryolipolysis and ATX\u2010101"],"prefix":"10.1111","volume":"21","author":[{"given":"H. Ray","family":"Jalian","sequence":"first","affiliation":[{"name":"Rebecca Fitzgerald Dermatology  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Rebecca Fitzgerald Dermatology  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beta","family":"Bowen","sequence":"additional","affiliation":[{"name":"AbbVie Inc  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvia","family":"Gamio","sequence":"additional","affiliation":[{"name":"AbbVie Inc  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"40","article-title":"Final data from the condition of submental fullness and treatment outcomes registry (CONTOUR)","volume":"18","author":"Palm MD","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1090820X12452554"},{"key":"e_1_2_10_4_1","first-page":"54","article-title":"Neck contouring and treatment of submental adiposity","volume":"16","author":"Thomas WW","year":"2017","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001648"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2008.10.008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.2017.040"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000699"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.22440"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2017.0102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000578"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.04.028"},{"key":"e_1_2_10_13_1","unstructured":"Accessed May 12 2020.https:\/\/www.coolsculpting.com\/pdfs\/CSC125713\u2010v2_Important_Safety_Information.pdf"},{"key":"e_1_2_10_14_1","unstructured":"Accessed May 12 2020.https:\/\/media.allergan.com\/actavis\/actavis\/media\/allergan\u2010pdf\u2010documents\/product\u2010prescribing\/20180205\u2010KYBELLA\u2010USPI\u201073179US10.pdf"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamafacial.2017.0112"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14909","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14909","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:31:42Z","timestamp":1692829902000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jocd.14909"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14909","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]},"assertion":[{"value":"2021-10-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}