{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:24:04Z","timestamp":1759937044448,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpigmentation conditions can affect all skin types but occur more frequently in darker skin. Because many factors have been implicated in the etiologies of these disorders, multi\u2010targeted approaches may be required to achieve a better overall outcome in a diverse patient population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study was to investigate the safety and efficacy of a combination regimen of a comprehensive cosmetic brightening agent (LYT2) with a broad blend of antioxidants (LVS) to reduce hyperpigmentation and improve overall skin appearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The combination of LYT2 and LVS, in addition to a basic skincare routine, was evaluated in subjects of either Caucasian or Asian (a majority of whom were Indian) descent, presenting with moderate\u2010to\u2010severe hyperpigmentation. Efficacy evaluations consisted of investigator clinical grading of overall hyperpigmentation, skin tone evenness, and radiance, as well as subject self\u2010assessment questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immediate and progressive improvement was noted by the investigators for all assessed parameters. At the end of the 12\u2010week study, investigators observed a 45% mean decrease from baseline for overall hyperpigmentation. In addition, a 50% improvement in skin tone evenness and a 58% increase in radiance was observed. These investigator assessments were matched by good patient scores for self\u2010perceived efficacy parameters and high overall satisfaction. One patient (7%) showed a treatment\u2010related adverse event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combination skincare regimen that combines the pigmentation control of LYT2 with the broad antioxidant defense of LVS is a well\u2010tolerated and effective treatment option to improve the appearance of facial hyperpigmentation and make skin more radiant.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14915","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T19:12:25Z","timestamp":1647285145000},"page":"2082-2088","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical assessment of a circadian\u2010based antioxidant system combined with a comprehensive brightening serum in diverse subjects with moderate\u2010to\u2010severe facial hyperpigmentation"],"prefix":"10.1111","volume":"21","author":[{"given":"Sachit","family":"Shah","sequence":"first","affiliation":[{"name":"BC Laser and Skincare Clinic  Surrey British Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelly","family":"Manry","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth T.","family":"Makino","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-5847","authenticated-orcid":false,"given":"Rahul C.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"401","article-title":"Dyschromia in skin of color","volume":"13","author":"Kang SJ","year":"2014","journal-title":"J Drugs 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