{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:13:25Z","timestamp":1771564405785,"version":"3.50.1"},"reference-count":65,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Cyperus rotundus<\/jats:italic> essential oil (CREO) is an anti\u2010inflammatory and depigmenting agent that helps treat hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to evaluate the depigmenting effect of CREO on genital hyperpigmentation to that of arbutin (ARB), and to evaluate the association between genital lightening, genital self\u2010image, sexual performance, and life quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Three hundred and eight healthy people were categorized into three groups: the CREO group, the ARB group, and the cold cream group (CC). In genital pigmentation, the tristimulus colorimeter is used to assess erythema and pigmentation. In addition, we aided in the development of the female genital self\u2010image scale (FGSIS\u20104), the female sexual function index (FSFI), and the dermatology life quality index (DLQI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The reduction in genital hyperpigmentation was significantly greater in the CREO and ARB groups than in the CC group; in physician global assessment and patients\u2019 self\u2010assessment, the results in treated bikini with the CREO and ARB groups were excellent when compared with the CC. Furthermore, no adverse effects were found in the CREO group, but mild irritation was found in the ARB group; additionally, the percentage of hair growth, color and luminance reduction, and hair thickness were significantly reduced in the CREO group only. In addition, there were significantly different in FGSIS, FSFI, and DLQI between the CREO and ARB groups and the CC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CREO is equivalently efficacious in decreasing pigmentation, inflammation, and hair growth in the genital area. Positive changes boost female genital self\u2010image, self\u2010esteem, and sexual performance. Improving sexual health has a positive impact on quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14918","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T18:34:02Z","timestamp":1647369242000},"page":"4490-4502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genital whitening with topical <i>Cyperus rotundus<\/i> oil enhances sexuality and quality of life"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-1347","authenticated-orcid":false,"given":"Ghada F.","family":"Mohammed","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Sexology Faculty of Medicine Suez Canal University  Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6418-6647","authenticated-orcid":false,"given":"Mohammed Saleh","family":"Al\u2010Dhubaibi","sequence":"additional","affiliation":[{"name":"Dermatology Department of Medicine College of Medicine Shaqra University  Dawadmi Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam Lotfy","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of obstetrics and gynecology faculty of medicine Suez Canal University  Ismailia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.14402"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02646830701759793"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10508-013-0102-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.03.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-8080(10)35494-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/713847124"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.02071.x"},{"key":"e_1_2_9_9_1","first-page":"387","article-title":"Common dermatologic disorders in skin of color: a comparative practice survey","volume":"80","author":"Alexis AF","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1971.04000240035004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1965.160"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2014.893185"},{"key":"e_1_2_9_13_1","first-page":"3502","article-title":"Alpha arbutin as a skin lightening agent: a review","volume":"13","author":"Chandorkar N","year":"2021","journal-title":"Int J Pharm Res"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14959"},{"key":"e_1_2_9_15_1","unstructured":"https:\/\/www.who.int\/medicines\/areas\/quality_safety\/quality_assurance\/resources\/index\u2010of\u2010pharmacopoeias_may_2019.pdf?ua=1. 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