{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:17:03Z","timestamp":1787876223970,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>S100A8<\/jats:italic>\u00a0single nucleotide polymorphism (SNP) and S100A8 blood level are related to many inflammatory disorders with no available conclusion in psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to evaluate the possible role of S100A8 in psoriasis pathogenesis through analyzing its <jats:italic>S100A8<\/jats:italic> (rs3806232) gene polymorphism and S100A8\u00a0serum level in psoriasis vulgaris patients, in addition to correlate the detected results with severity psoriasis in those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study was conducted on 50 patients having psoriasis vulgaris, and 26 controls. Severity of psoriasis was evaluated using psoriasis area and severity index (PASI) score. S100A8\u00a0serum level and <jats:italic>S100A8<\/jats:italic> (rs3806232) SNP were evaluated by ELISA and polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum S100A8\u00a0level was significantly higher in psoriatic patients than controls and was positively correlated with PASI score (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.826, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). <jats:italic>S100A8<\/jats:italic> (rs3806232) AA genotype and A allele were significantly increased among psoriasis patients than controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) increasing risk of psoriasis development by about 5, 12, and 6 times than AG, GG, and G alleles. AA genotype was significantly associated with psoriasis severity (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) and high S100A8\u00a0serum levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Circulating S100A8 could associated with disease severity and have an active role in psoriasis pathogenesis. <jats:italic>S100A8<\/jats:italic> (rs3806232) SNP (AA genotype and A allele) might contribute to development and severity of psoriasis in the Egyptian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14928","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T18:34:34Z","timestamp":1647974074000},"page":"4974-4982","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>S100A8<\/i> (rs3806232) gene polymorphism and S100A8 serum level in psoriasis vulgaris patients: A preliminary 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