{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:08Z","timestamp":1788994748078,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) is a protein that plays a key role in the pathophysiology of chronic inflammatory disorders like psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The goal of this study was to see whether the TNF\u2010\u03b1 gene \u2010238G&gt;A polymorphism was linked to psoriasis susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study comprised 90 psoriasis patients and ninety healthy controls. For the TNF\u2010\u03b1 gene \u2010238G&gt;A polymorphism, genomic DNA was extracted and genotyped using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Psoriasis patients had higher frequencies of the A allele and the AA genotype than the control group, and psoriasis was linked to the AA genotype (OR\u00a0=\u00a04.25, 95% CI\u00a0=\u00a01.37\u201313.1, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) and the A allele (OR\u00a0=\u00a01.55, 95% CI\u00a0=\u00a01.01\u20132.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Patients with a family history of psoriasis showed an increase in the frequency of the AA genotype compared with GG and GA genotypes (46.7%, 36.7%, and 16.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.003, respectively). Furthermore, psoriasis patients with the AA genotype were discovered more commonly among those under 30\u00a0years of age and male patients than those with the GG and GA genotypes, but the differences were not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TNF\u2010\u03b1 gene \u2010238G&gt;A polymorphism has been related to an increased incidence of psoriasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14940","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T13:44:42Z","timestamp":1648388682000},"page":"2662-2667","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["TNF\u2010\u03b1 gene \u2010238G&gt;A polymorphism is associated with psoriasis patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-1945","authenticated-orcid":false,"given":"Raziye","family":"Akc\u0131lar","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazl\u0131","family":"Dizen Namdar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulya","family":"Y\u00fckc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Biophysics Faculty of Medicine K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selve","family":"Arslan Utku","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13854"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-004-0041-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1221"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.7.3195"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.3.213"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12337469"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1994.tb06244.x"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"69","article-title":"Gene polymorphisms of TNF\u2010238G\/A, TNF\u2010308G\/A, IL10\u20101082G\/A, TNFAIP3, and MC4R and comorbidity occurrence in a Romanian population with psoriasis","volume":"11","author":"Voiculescu VM","year":"2018","journal-title":"J Med Life"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07993.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.039164"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068827"},{"issue":"27","key":"e_1_2_10_14_1","first-page":"101050","article-title":"Tumor necrosis factor\u2010\u03b1 gene promoter \u2010308 and \u2010238 polymorphisms and its serum level in psoriasis","volume":"12","author":"Hagag MM","year":"2021","journal-title":"Biochem Biophys Rep"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13482"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700822"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"118","article-title":"Tumor necrosis factor\u2010alpha gene polymorphism in psoriasis","volume":"14","author":"Arias AI","year":"1997","journal-title":"Exp Clin Immunogenet"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12894"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00022-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05166.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00242-7"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0392-9"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00541.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.5.525"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04465.x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00654.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:30:28Z","timestamp":1692829828000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,9]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jocd.14940"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14940","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,9]]},"assertion":[{"value":"2021-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}