{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:19:56Z","timestamp":1783948796823,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is an acquired pigmentation disorder with a complex multifactorial etiopathogenesis. Oral tranexamic acid (TA) is a promising drug for its treatment and may enhance outcomes when used in combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide evidence of the efficacy and safety of oral TA as a monotherapy, and in combination with a triple combination cream, for treating melasma in the Hispanic population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four female Hispanic patients with melasma were randomly assigned to receive 325\u00a0mg of oral TA every 12\u00a0h plus f\u2010TCC (fluocinolone\u2010based triple combination cream) every 24\u00a0h (group A) or 325\u00a0mg of oral TA every 12\u00a0h (group B) for 8\u00a0weeks, after which both groups were crossed\u2010over, and treated for an additional 8\u00a0weeks. Evaluations of the mMASI score, the melanin index, and the MelasQoL were made at baseline and Weeks 4, 8, 12, and 16.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a 50.04% and 65.45% improvement in mMASI at Weeks 4 and 8, respectively, in group A, compared to baseline, while for Week 16, an improvement of 76.85% was achieved in group B compared to baseline. Highest scores were consistent with the use of the combined treatment modality in both groups, and were evidenced by the values of the melanin index obtained. There was no significant difference in MelasQoL scores between the 2\u00a0groups. No serious side effects were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of oral TA and f\u2010TCC is more effective than oral TA alone in the treatment of severe melasma in Hispanic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14942","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T13:44:42Z","timestamp":1648388682000},"page":"3451-3457","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Oral tranexamic acid with a triple combination cream versus oral tranexamic acid monotherapy in the treatment of severe melasma"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7695-8424","authenticated-orcid":false,"given":"Jessica Carolina","family":"Martinez\u2010Rico","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital \u201cDr. Jose Eleuterio Gonzalez\u201d Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1637-7956","authenticated-orcid":false,"given":"Sonia","family":"Chavez\u2010Alvarez","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital \u201cDr. Jose Eleuterio Gonzalez\u201d Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6299-1821","authenticated-orcid":false,"given":"Maira Elizabeth","family":"Herz\u2010Ruelas","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital \u201cDr. Jose Eleuterio Gonzalez\u201d Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Axel","family":"Sosa\u2010Colunga","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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