{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T05:45:00Z","timestamp":1794203100464,"version":"4.8.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is a common skin disorder resulting from the destruction of melanocytes. Hepatitis C virus (HCV) infection has been linked to a variety of extrahepatic manifestations, including skin diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To measure the prevalence of HCV\u2010seroreactivity among vitiligo patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study included 108 vitiligo patients. Serum anti\u2010HCV antibodies were detected by chemiluminescence immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen patients (16.7%) out of 108 were HCV\u2010reactive; all of them had adult\u2010onset vitiligo. They represented approximately 34.6% of the total patients with adult\u2010onset vitiligo (52 patients). On the contrary, all patients with childhood\u2010onset vitiligo were HCV\u2010non\u2010reactive. Moreover, adult\u2010onset vitiligo was significantly associated with HCV\u2010seroreactivity (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Also, there was a significant difference between HCV\u2010reactive and HCV\u2010non\u2010reactive vitiligo patients regarding the age of patients and their ages at the onset of vitiligo (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HCV may be the triggering factor for adult\u2010onset vitiligo, particularly in regions with a high prevalence of HCV. Therefore, patients with adult\u2010onset vitiligo, rather than childhood\u2010onset disease, should be screened for associated HCV infection in HCV\u2010endemic regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14946","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T09:55:38Z","timestamp":1648547738000},"page":"4983-4989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hepatitis C virus infection could be a risk factor for adult\u2010onset vitiligo in Egyptian patients: A cross\u2010sectional study"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5490-9672","authenticated-orcid":false,"given":"Manal M.","family":"Fawzy","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9400-7822","authenticated-orcid":false,"given":"Noha M.","family":"Hammad","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed L.","family":"Sharaf","sequence":"additional","affiliation":[{"name":"Department of Tropical Medicine, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2600-4021","authenticated-orcid":false,"given":"Fathia","family":"Khattab","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology, Faculty of Medicine Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.10.048"},{"key":"e_1_2_10_3_1","volume-title":"Global hepatitis report 2017","author":"Centre for Disease Analysis. 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