{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T13:02:44Z","timestamp":1765976564040,"version":"3.41.0"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The close balance between <jats:italic>Cutibacterium acnes<\/jats:italic> and the skin flora, particularly between <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> phylotypes, has been suggested to play an important role in the onset of acne. <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> has been classified into ribotypes (RTs) based on polymorphisms in its 16S rRNA sequence, with RT4 and RT5 being associated with the onset of acne and RT6 with healthy skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The present study investigated the impact of erythritol on the growth of <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic> strains classified into different RTs and attempted to elucidate the molecular mechanisms underlying its effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Culturing tests were performed on several RTs of <jats:italic>C.\u00a0acnes<\/jats:italic> with or without erythritol. A transcriptional analysis of HM554 (RT6) and HM514 (RT5) was also conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The growth of RT2 and RT6, RTs associated with healthy skin, was significantly promoted in a medium containing 10% (W\/W) erythritol, whereas that of RT1, RT3, RT4, RT5, and RT8, RTs associated with the development of acne, was inhibited. A RNA\u2010seq analysis of HM554 showed that the expression of six genes (<jats:italic>EIGs<\/jats:italic>) potentially involved in carbohydrate metabolism was strongly induced by the presence of 10% erythritol (Log<jats:sub>2<\/jats:sub> fold change &gt;2.0 and <jats:italic>p<\/jats:italic>\u2010value &lt;0.05). A comparative expression analysis by qPCR revealed that <jats:italic>EIGs<\/jats:italic> other than <jats:italic>g3pD<\/jats:italic> were strongly induced by erythritol in HM514, similar to HM554, whereas <jats:italic>g3pD<\/jats:italic> was only slightly induced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Erythritol inhibited the growth of RTs associated with acne and promoted that of RTs associated with healthy skin. The enzyme encoded by <jats:italic>g3pD<\/jats:italic> may play an important role in the metabolism of erythritol and the dissolution of its growth inhibitory effects on <jats:italic>C<\/jats:italic>.\u00a0<jats:italic>acnes<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14958","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:15:10Z","timestamp":1648847710000},"page":"5049-5057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Ribotype\u2010dependent growth inhibition and promotion by erythritol in <i>Cutibacterium acnes<\/i>"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7466-895X","authenticated-orcid":false,"given":"Tadashi","family":"Fujii","sequence":"first","affiliation":[{"name":"Research &amp; Development Center B Food Science Co., Ltd.  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Tochio","sequence":"additional","affiliation":[{"name":"Research &amp; Development Center B Food Science Co., Ltd.  Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Food, Aroma, and Cosmetic Chemistry Faculty of Bioindustry Tokyo University of Agriculture  Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.157"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2011.03.022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001367"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3920\/BM2012.0062"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14967"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep39491"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2847"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.21"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms7050128"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00023-15"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.06.615"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.15562\/bmj.v8i3.1514"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00003-13"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2015.4033"},{"key":"e_1_2_9_16_1","unstructured":"European Food Safety Authority. Opinion of the Scientific Committee on Food on Erythritol (opinion expressed on 5 March 2003).http:\/\/ec.europa.eu\/comm\/food\/fs\/sc\/scf\/reports\/scf_reports_16.pdf"},{"key":"e_1_2_9_17_1","article-title":"Erythritol is more effective than xylitol and sorbitol in managing oral health endpoints","volume":"16","author":"Cock PD","year":"2016","journal-title":"Int J Dent"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12037"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14201"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/aem.38.4.585-589.1979"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgeb.2016.03.002"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)93533-7"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1414622111"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2006.00273.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.02.017"},{"key":"e_1_2_9_26_1","unstructured":"Shiseido Company Limited.Shiseido Discovers Sensitive Skin is Low in Skin Microbiome Diversity. 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