{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:30:43Z","timestamp":1787506243156,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T00:00:00Z","timestamp":1649721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Botulinum toxin type A (BTX\u2010A) has been used experimentally under various dermatological conditions. Recent studies have revealed a preventive effect of BTX\u2010A against ultraviolet B (UVB)\u2010induced skin hyperpigmentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined the effect of BTX\u2010A for the treatment of UVB\u2010induced hyperpigmentation in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>A prospective, double\u2010blind, randomized controlled trial was conducted. UVB irradiation induced five separate hyperpigmented squares on the abdomen. Seven days after irradiation, all squares were randomly assigned to five intervention groups: control, 0.9% normal saline injection, 12 units (1:2.5), 6 units (1:5), and 4 units (1:7.5) of onabotulinum toxin injections. The lightness index (L*), hyperpigmentation improvement score rated by a blinded physician, and participant satisfaction scores were obtained at 14, 21, and 28\u00a0days after injection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen participants (mean age 36.9\u00a0years, Fitzpatrick skin types III\u2010IV) completed the study. The BTX\u2010A (1:2.5)\u2010treated site had a lower degree of hyperpigmentation at all time points, as measured by mean L* and hyperpigmentation improvement scores. However, there were no statistically significant differences between the groups. Participants were most satisfied with the control site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intradermal BTX\u2010A injection had no therapeutic effect on UVB\u2010induced hyperpigmentation. However, the role of BTX\u2010A injections in the treatment of other hyperpigmentary conditions requires further elucidation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.14966","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T11:40:42Z","timestamp":1649072442000},"page":"3343-3350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Study of botulinum toxin type A for the treatment of ultraviolet B\u2010induced hyperpigmentation: A prospective, randomized, controlled trial"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-5796","authenticated-orcid":false,"given":"Natthachat","family":"Jurairattanaporn","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University  Bangkok 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