{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:27:58Z","timestamp":1787974078305,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100019603","name":"Faculty of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019603","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009570","name":"Srinakharinwirot University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009570","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Probiotics provide benefits for reducing acne. Previous studies showed an anti\u2010inflammatory effect of\n Lactobacillus paracasei<\/jats:italic>\n . However, the clinical evidence of topical probiotic lotion and acne treatment is still lacking.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To evaluate the efficacy and safety of probiotic\u2010derived lotion compared with 2.5% benzoyl peroxide in the treatment of mild\u2010to\u2010moderate acne vulgaris.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Topical probiotic\u2010derived lotion was formulated from cell\u2010free supernatant of\n L<\/jats:italic>\n .\u00a0\n paracasei<\/jats:italic>\n MSMC 39\u20101. In\n vitro<\/jats:italic>\n study showed the ability of the supernatant to inhibit both antibiotic\u2010resistance and\u2010susceptibility strains of\n C.\u00a0acnes<\/jats:italic>\n and inhibit tumor necrosis factor\u2010\u03b1. The patients with mild\u2010to\u2010moderate acne vulgaris on the face were randomized to receive topical probiotic\u2010derived lotion or 2.5% benzoyl peroxide. Acne lesion counts, erythema index, and side effects were assessed after 2 and 4\u00a0weeks of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n One hundred and four acne vulgaris patients were enrolled. After four weeks of treatment, the inflammatory acne lesion counts and erythema index significantly decreased compared with the baseline in both the probiotic\u2010derived lotion group and 2.5% benzoyl peroxide group (\n p<\/jats:italic>\n < 0.001 in both groups) without statistically significant difference between the two groups (\n p<\/jats:italic>\n > 0.05). However, the comedones were not affected in both groups. Four patients (7.69%) treated with probiotic\u2010derived lotion and 14 patients (26.92%) treated with 2.5% benzoyl peroxide reported treatment\u2010associated side effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Probiotic\u2010derived lotion is safe and effective for treating mild to moderate acne vulgaris, a comparable outcome with 2.5% benzoyl peroxide. It could be an alternative treatment of acne with more minor side effects.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.14971","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T14:34:05Z","timestamp":1649169245000},"page":"5092-5097","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Efficacy of probiotic\u2010derived lotion from\n Lactobacillus paracasei<\/i>\n MSMC 39\u20101 in mild to moderate acne vulgaris, randomized controlled trial"],"prefix":"10.1111","volume":"21","author":[{"given":"Sunattha","family":"Sathikulpakdee","sequence":"first","affiliation":[{"name":"Skin Center Faculty of medicine Srinakharinwirot University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silada","family":"Kanokrungsee","sequence":"additional","affiliation":[{"name":"Skin Center Faculty of medicine Srinakharinwirot University Bangkok 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excellence in probiotics Strategic wisdom and research institute Srinakharinwirot University Bangkok Thailand"},{"name":"Department of Microbiology Faculty of Medicine Srinakharinwirot University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200308000-00009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12149"},{"key":"e_1_2_11_4_1","first-page":"44","article-title":"The pathogenesis of acne","volume":"13","author":"Knor T","year":"2005","journal-title":"Acta Dermatovenerol Croat"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.8.3158-3165.1995"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06933.x"},{"key":"e_1_2_11_7_1","first-page":"6","article-title":"Antibiotic resistance in the topical treatment of acne 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