{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T13:54:21Z","timestamp":1775829261599,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is a chronic, inflammatory skin disorder of pilosebaceous units. Tranexamic acid (TXA) acts as a plasmin inhibitor to reduce blood loss and is also used to treat rosacea due to its anti\u2010inflammatory effects. Some parts of the pathogenesis of rosacea are similar to inflammatory acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aimed to evaluate the efficacy of 10% TXA serum in treating acne and its adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, placebo\u2010controlled, split\u2010face study was performed on 18\u00a0mild\u2010to\u2010moderate acne patients. Patients applied 10% TXA serum on one side of the face and placebo on another side twice daily for 8\u00a0weeks. Acne lesion counts and adverse effects were evaluated every 2\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences in total inflammatory acne counts were observed between TXA and placebo since Week 4 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008). TXA mainly reduced papules and pustules, as papule counts significantly decreased since the 8th week (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.046) and pustule counts significantly reduced since Week 8 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.033). Moreover, physicians also found that TXA serum reduced the redness of the skin, corresponding with the imaging from VISIA<jats:sup>\u00ae<\/jats:sup> Skin Analysis. The anti\u2010inflammatory effect of TXA resulted in less PIE and PIH. Adverse effects, including erythema and scaling, were treated by applying any moisturizing cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Topical 10% TXA can reduce inflammatory acne effectively. Adverse effects were minor and treat easily.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14972","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T08:27:00Z","timestamp":1649320020000},"page":"4515-4522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adjunctive treatment for acne vulgaris by tranexamic acid"],"prefix":"10.1111","volume":"21","author":[{"given":"Anshittha","family":"Charoenwattanayothin","sequence":"first","affiliation":[{"name":"School of Anti\u2010Aging and Regenerative Medicine Mae Fah Luang University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tawee","family":"Saiwichai","sequence":"additional","affiliation":[{"name":"Faculty of Public Health Mahidol University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-8956","authenticated-orcid":false,"given":"Sirintip","family":"Chaichalotornkul","sequence":"additional","affiliation":[{"name":"School of Anti\u2010Aging and Regenerative Medicine Mae Fah Luang University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"1","article-title":"A comprehensive review of acne vulgaris","volume":"6","author":"Mohiuddin AK","year":"2019","journal-title":"Clin Res Dermatol Open Access"},{"key":"e_1_2_10_3_1","first-page":"585","volume-title":"Dermatology Essentials","author":"Bolognia JL","year":"2018"},{"issue":"9","key":"e_1_2_10_4_1","first-page":"27","article-title":"The role of inflammation in the pathology of acne","volume":"6","author":"Tanghetti EA","year":"2013","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mku009"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12026"},{"issue":"8","key":"e_1_2_10_7_1","first-page":"753","article-title":"Topical tranexamic acid as a promising treatment for melasma","volume":"19","author":"Ebrahimi B","year":"2014","journal-title":"J Res Med Sci"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"174","article-title":"Study evaluating the efficacy of topical and injected tranexamic acid in treatment of melasma","volume":"1","author":"Steiner D","year":"2009","journal-title":"Surg Cosmet Dermatol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2015.04.012"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.09.074"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.12.067"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12724"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14764172.2012.685478"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.13900"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2012.0788"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:45:29Z","timestamp":1748353529000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":15,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/jocd.14972"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14972","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"2021-06-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}