{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:23:13Z","timestamp":1778948593163,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne tarda (AT) is typically known as adult acne and most preferably affected 25\u201345 age\u00a0groups. Used isotretinoid monotherapy is not effective and also produces side effects from long treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study assesses the effectiveness of combined treatment of oral isotretinoid with topical chemical peeling (20% salicylic and 10% mandelic acid known as SM peeling) by a comparative double\u2010blind randomized single\u2010center interventional open\u2010label study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total fifty\u2010eight participants AT outpatients (25\u201345 age groups) attending for diagnosis in two groups and effectiveness of proposed combined treatments were determined at baseline and follow\u2010up within 4\u2010week interval. Briefly group A (<jats:italic>n\u00a0=<\/jats:italic>\u00a028) received 0.5\u00a0mg\/kg of oral isotretinoin once daily for 16\u00a0weeks and group B (<jats:italic>n\u00a0=<\/jats:italic>\u00a030) received the same oral dose, addition with SM peeling every 4\u00a0weeks interval for 16\u00a0weeks. After 4\u00a0weeks, treatment efficacy was assessed based on Michelson's acne severity index (MASI) and visual analog scale (VAS), further validated using statistical tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on MASI and VAS scores, combined treatment was significantly effective than the monotherapy. The pre\u2010 and post\u2010treatment analyses of response\u00a0to scarring, inflammatory components at baseline and at the end of treatment were also statistically significant with <jats:italic>p\u00a0&gt;\u00a0<\/jats:italic>0.008.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The above investigation revealed that the combination of\u00a0oral isotretinoin with SM peeling was highly effective and could be used\u00a0as newer therapy against AT without any serious side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14973","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T08:35:32Z","timestamp":1649320532000},"page":"4398-4404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Randomized prospective study of low\u2010dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne 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