{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:11:09Z","timestamp":1790838669675,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Pyruvic acid in concentration between 40% and 70% is currently been used as a superficial to medium peeling agent for various dermatological indications including acne. However, there is a paucity of its efficacy studies on acne in Asians, particularly in Indian skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our study was aimed at determining the efficacy and tolerability of 40% pyruvic acid on acne, post\u2010acne hyperpigmentation, and scarring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A total of 30 patients with active acne, post\u2010acne scarring, and hyperpigmentation were included. Patients already on oral antibiotic or topical antiacne medication for the last 4\u00a0weeks, a history of hypertrophic scarring, keloids, active or recurrent herpes were excluded. Chemical peeling was done at 2\u00a0weekly interval from 0 to 12\u00a0weeks. An objective assessment of active acne lesions, post\u2010acne scarring, and hyperpigmentation was made at each visit that is at 0, 4,8,12, and 24\u00a0weeks. Patients were followed up 2\u00a0weeks after the last peel and again at 24\u00a0weeks. Permission from the ethical committee was also obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was significant decrease in the number of comedones at 12\u00a0weeks compared with 0\u00a0week (<jats:italic>p\u00a0=<\/jats:italic>\u00a00.001). Similarly, the number of papules decreased from o weeks to 12\u00a0weeks (<jats:italic>p<\/jats:italic> value 0.004). Acne score improved from 0\u00a0weeks to 12\u00a0weeks (<jats:italic>p\u00a0&lt;<\/jats:italic>\u00a00.0001); from 0\u00a0weeks to 24\u00a0weeks (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.011). and hyperpigmentation improved from 0\u00a0weeks to 12\u00a0weeks (<jats:italic>p\u00a0=<\/jats:italic>\u00a00.008); from 0\u00a0weeks to 24\u00a0weeks (<jats:italic>p\u00a0=<\/jats:italic>\u00a00.021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed a significant decrease in comedones, papules, acne score, and hyperpigmentation, though acne scar did not improve significantly. However, a study with larger sample is needed due to the limited number of patient population in our study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14974","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T08:35:32Z","timestamp":1649320532000},"page":"4405-4409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The efficacy and tolerability of 40% pyruvic acid peel on acne vulgaris, post acne scar and hyperpigmentation in Indians"],"prefix":"10.1111","volume":"21","author":[{"given":"Chitralekha","family":"Keisham","sequence":"first","affiliation":[{"name":"Department of Dermatology Jawaharlal Nehru Institute of Medical Sciences  Porompat Imphal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lokendra Singh","family":"Yumnam","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Nehru Institute of Medical Sciences  Porompat Imphal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00759.x"},{"key":"e_1_2_10_3_1","first-page":"325","article-title":"Use of pyruvic acid in the treatment of actinic keratoses: a clinical and histopathologic study","volume":"47","author":"Griffin TD","year":"1991","journal-title":"Cutis"},{"key":"e_1_2_10_4_1","first-page":"283","article-title":"Treatment of warts with topical pyruvic acid: with and without added 5\u2010fluorouracil","volume":"62","author":"Halasz CL","year":"1998","journal-title":"Cutis"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"526","article-title":"Clinical and instrumental evaluation of skin improvement after treatment with new 50% pyruvic acid peel","volume":"32","author":"Berardesca E","year":"2006","journal-title":"Dermatol Surg"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30002.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90680-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113451"},{"issue":"2","key":"e_1_2_10_9_1","first-page":"1","article-title":"Pyruvic acid as a new therapeutic peeling agent in acne, melasma and warts","volume":"2","author":"Tosson Z","year":"2006","journal-title":"Egyp Dermatol Online J"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.181991"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14974","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.14974","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.14974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:45:31Z","timestamp":1748353531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.14974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,23]]},"references-count":9,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/jocd.14974"],"URL":"https:\/\/doi.org\/10.1111\/jocd.14974","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,23]]},"assertion":[{"value":"2022-02-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}