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Possible outcomes of the inflammatory acne lesions are acne scars which, although they can be treated in several ways, may have a negative psychological impact on social life and relationships. There are three levels of acne: mild, moderate, and severe. The main types of acne scars are atrophic and hypertrophic scars. The pathogenesis of acne scarring is still not fully understood, but several hypotheses have been proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this review is phytoconstituents\u2010loaded nanomedicines for the management of acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An online literature assessment was steered for the acne, phytochemical composition, and nanomedicines, types of acne, types of nanotechnology. Appropriate information were taken from different electronic scientific databases such as Web of Science, Elsevier, Science Direct, Springer, PubMed, Google Scholar, etc., Additional data was summarized from textbooks, local prints, and scripts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nanotechnology\u2010based nanomedicines provide a great coincidence for the enhancement in the efficacy and safety of pharmaco\u2010therapeutic agents for acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this review, we discuss the phytoconstituent that are natural compounds present in plants extensively used for the anti\u2010acne activity. Phytochemicals target cytokine signaling pathways and thus exhibit their anti\u2010acne activity. We further outline the advantages of loading phytoconstituents as a drug in nanocarriers such as emulsion, niosomes, SLN, and nanocrystal for better and improved topical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review is mainly focused on the usage of herbal nanomedicines in acne, nano delivery carriers used in the delivery of phytoconstituents with an improved therapeutic profile and reduced toxicity. In recent years, phytoconstituents showing their anti\u2010acne potential, and phytoconstituents\u2010loaded nanomedicines have high treatment potential in the management of acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.14999","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T09:43:29Z","timestamp":1650275009000},"page":"3240-3255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Phytoconstituents\u2010loaded nanomedicines for the management of acne"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-0847","authenticated-orcid":false,"given":"Abdul","family":"Qadir","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Education and Research, Jamia Hamdard  New Delhi India"},{"name":"Department of Research and Developments Herbalfarm Health care Private Limited  New Delhi 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