{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:19:06Z","timestamp":1792109946351,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data suggest that hyaluronic acid (HA) fillers using VYC technology have a higher incidence of delayed\u2010onset nodule development at facial injection sites than earlier HA products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the incidence of delayed\u2010onset nodules with VYC products based on a single experienced injector.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Patients with delayed\u2010onset nodules after injections with VYC\u201020L, VYC\u201017.5L, and VYC\u201015L were identified by retrospective chart review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since 2010, 2139 patients received injections from the same physician with combinations of VYC\u201020L (57.6% of patients; 2.4\u00a0syringes\/patient), VYC\u201017.5L (23.9%; 1.5), or VYC\u201015L (18.5%; 1.5). Seven female patients (mean age, 62\u00a0years) developed delayed\u2010onset nodules for an overall incidence of 0.33%. A potential inflammatory trigger (reported by 6 patients) occurred 1\u2013168\u00a0days prior to nodule development. Nodule biopsy in 1 patient confirmed a foreign\u2010body granuloma. The most effective treatment incorporated prednisone with or without hyaluronidase, and in 2 patients, nodules resolved spontaneously. The incidence of delayed\u2010onset nodules was not associated with injection technique or amount of product used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>VYC\u2010associated incidence of delayed\u2010onset nodules (0.33%) was lower than earlier estimates from previous studies. In the current analysis, VYC\u201015L had a rate of delayed reactions comparable with non\u2010VYC products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15013","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T07:27:46Z","timestamp":1650612466000},"page":"2379-2386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Incidence and treatment of delayed\u2010onset nodules after VYC filler injections to 2139 patients at a single Canadian clinic"],"prefix":"10.1111","volume":"21","author":[{"given":"Jason K.","family":"Rivers","sequence":"first","affiliation":[{"name":"Pacific Derm The Department of Dermatology and Skin Science University of British Columbia  Vancouver British Columbia 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