{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:46:26Z","timestamp":1783734386340,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Botulinum toxin and hyaluronic acid (HA) filler injections are popular minimally invasive cosmetic procedures owing to their convenience, efficiency, and durability; however, adverse reactions often occur.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>We describe the delayed hypersensitivity reaction that occurred after sequential injections of botulinum toxin and HA filler.<\/jats:p><\/jats:sec>Results<\/jats:title>The histopathologic and dermatoscopic findings suggested a delayed hypersensitivity reaction with the formation of a dermal foreign body granuloma. The rash resolved 2 months following treatment with antihistamines and topical steroids cream.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>We assume that local trauma during the blepharoplasty stimulated an immune response, which was the basis for this complication.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15016","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T09:28:41Z","timestamp":1650706121000},"page":"2374-2378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Delayed complication of botulinum toxin and hyaluronic acid filler injections: A case report"],"prefix":"10.1111","volume":"21","author":[{"given":"Dihui","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Dermatology Beijing ChuiYangLiu Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology MEIYAN Aesthetic Plastic Medical Clinic Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghong","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pathology Beijing ChuiYangLiu Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaowei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing ChuiYangLiu Hospital Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13266"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07074.x"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"165","article-title":"An adverse reaction after hyaluronic acid filler application: a case report","volume":"27","author":"Vidi\u010d M","year":"2018","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12298"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4081\/dr.2015.5851"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14164"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02354.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002061"},{"key":"e_1_2_9_10_1","first-page":"295","article-title":"Dermal fillers in aesthetics: an overview of adverse events and treatment approaches","volume":"6","author":"Funt D","year":"2013","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12620"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2006.01.049"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000418"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13734"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-013-0107-3"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15016","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15016","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T22:33:22Z","timestamp":1692830002000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1111\/jocd.15016"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15016","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"2021-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}