{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:15:43Z","timestamp":1791216943303,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Filler injection for lower eyelid rejuvenation remains a difficult subject due to many complicated anatomic changes as the face ages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To propose an alternative, simple, and effective filler injection method in lower eyelids for Asian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Any patient who has tear trough deformities, infra\u2010orbital hollows, nasojugal grooves, dark eye circles, as well as mild eyebags is a potential candidate for this method. Our filler choice is injectable poly\u2010<jats:sc>d<\/jats:sc>,<jats:sc>l<\/jats:sc>\u2010lactic acid (PDLLA; AestheFill; REGEN). PDLLA must be reconstituted with sterile water for injection (SWFI) before administration. When the patient's troughs, grooves, or volume deficit are classes II and III, 3\u20134\u00a0ml of SWFI and 1\u00a0ml of lidocaine are used. When the deficits are class I, 5\u20137\u00a0ml of SWFI and 1\u00a0ml of lidocaine are used. With the fanning injection technique, a wide region that covers all the deficits is evenly injected. The depth is under the dermis layer. The total amount of filler injection is not more than 2\u00a0ml on each side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since 2019, we have injected more than 100 patients by following these steps in Taiwan. The level of patient satisfaction is high. Only some mild and transient post\u2010injection complications such as edema, erythema, and ecchymosis were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose an alternative, simple and effective method for non\u2010surgical lower eyelid rejuvenation for Asian patients. However, anyone who wants to perform this procedure should be well\u2010trained and knowledgeable about the anatomy, product, and procedure to prevent adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15047","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T11:35:30Z","timestamp":1651750530000},"page":"4328-4331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Nonsurgical lower eyelid rejuvenation using injectable poly\u2010<scp>d<\/scp>,<scp>l<\/scp>\u2010lactic acid in Asian patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Jui\u2010Yu","family":"Lin","sequence":"first","affiliation":[{"name":"Li\u2010An Medical Clinic  Taipei City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-478X","authenticated-orcid":false,"given":"Chuan\u2010Yuan","family":"Lin","sequence":"additional","affiliation":[{"name":"Li\u2010An Medical Clinic  Taipei City Taiwan"},{"name":"Kaohsiung Jourdenwell Aesthetic Clinic  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000001837"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.13475"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0b013e3181c82f90"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab116"},{"key":"e_1_2_9_6_1","first-page":"16","article-title":"Efficacy and safety of poly\u2010D, L\u2010lactic acid microspheres as subdermal fillers in animals","volume":"6","author":"Lin CY","year":"2019","journal-title":"Plast Aesthet Res"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000002829"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000003563"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.14730\/aaps.2019.01977"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001056"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.15047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.15047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:45:52Z","timestamp":1748353552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.15047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/jocd.15047"],"URL":"https:\/\/doi.org\/10.1111\/jocd.15047","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]},"assertion":[{"value":"2022-02-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}