{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:36Z","timestamp":1791492636400,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T00:00:00Z","timestamp":1653264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adult female acne (AFA) nowadays is a very common skin condition affecting mainly women aged between 25 and 40. The treatment of AFA could be challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study aim<\/jats:title>\n                    <jats:p>We evaluate and compare the efficacy and tolerability of a cream formulation containing two retinoid molecules (hydroxypinacolone\/retinyl palmitate) combined with Iris Florentina root extract and a complex of three oligopeptides (C) applied twice a day (morning and evening) alone or in combination (C\u2009+\u2009O) with a food supplement containing a mixture of prebiotic molecules (FOS&amp;GOS) zinc, lactoferrin, and niacinamide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and methods<\/jats:title>\n                    <jats:p>In a multicenter, randomized, assessor\u2010blinded, 12\u2010week trial, we assessed the efficacy of these two regimens in the evolution of AFA lesions (non\u2010inflammatory: NI\u2010L; inflammatory: IL; and total number of lesions: TL). Additional efficacy endpoints were the evolution of the 6\u2010point (from 0 to 5) GEA and Adult Female Acne Scoring Tool (AFAST) scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and eighty\u2010four women (mean age 32\u2009\u00b1\u20096\u2009years) with AFA agreed to participate after obtaining informed consent. They were randomized (2:1) to the topical product (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0123) (Group C) or to the combination (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a061) (Group C\u2009+\u2009O) treatment. All enrolled patients concluded the trial with no drop\u2010out. At baseline, NI\u2010L, IL, and TL acne lesion count were 15\u2009\u00b1\u20099, 9\u2009\u00b1\u20095, and 24\u2009\u00b1\u200914 in the Group C and 19\u2009\u00b1\u20098, 9\u2009\u00b1\u20094, and 29\u2009\u00b1\u200910 in Group C\u2009+\u2009O. In comparison with the number of the acne lesions at the baseline, both treatment regimens induced a significant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0001, ANOVA test) at Week 12 in NI\u2010L, IL, and TL by \u221254%, \u221263%, and\u2009\u2212\u200959% in Group C and by \u221255%, \u221273%, and\u2009\u2212\u200961% in the Group C\u2009+\u2009O, respectively. At Week 12, the absolute IL count reduction vs. baseline was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0158) greater in Group C\u2009+\u2009O (\u22127.0) in comparison with Group C (\u22125.5). The GEA absolute score reduction in Group C\u2009+\u2009O group was significantly greater in comparison with Group C (\u22121.5 vs. \u22121.1;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0097). In the Group C\u2009+\u2009O, a greater percentage of success treatment (defined as a GEA score of 0\/1 at Week 12) was observed in comparison with Group C (39% vs. 27%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.06). AFAST score at baseline was 2.4\u2009\u00b1\u20090.5 in group C and 2.8\u2009\u00b1\u20090.6 in group C\u2009+\u2009O. AFAST score was reduced by 21% and by 51% after 6 and 12\u2009weeks of treatment in group C and by 22% and 55% in group C\u2009+\u2009O, respectively. Both treatment regimens were well tolerated. Not relevant adverse events were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A cream containing retinoid molecules and Iris Florentina root extract is effective and well tolerated in the management of AFA. The treatment combination with a prebiotic and anti\u2010inflammatory food supplement offers an additional clinical benefit mainly in reducing inflammatory lesions and improving the severity acne score.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15074","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T03:07:47Z","timestamp":1652324867000},"page":"5716-5722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy of a retinoid complex plus anti\u2010inflammatory component cream alone or in combination with prebiotic food supplement in adult acne: A randomized, assessor\u2010blinded, parallel\u2010group, multicenter trial on 184 women"],"prefix":"10.1111","volume":"21","author":[{"given":"Jana","family":"Kazandjieva","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical University  Sofia 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