{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:30:02Z","timestamp":1771273802087,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Lagerstroemia indica<\/jats:italic> (<jats:italic>L.\u00a0indica<\/jats:italic>) is reported to have diverse biological activities including anti\u2010inflammatory, anti\u2010cancer, neuro\u2010regulatory, antidiabetic, and antioxidant activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study is to examine the potential of hair growth promotion and\/or hair loss prevention by <jats:italic>L.\u00a0indica<\/jats:italic> extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The effects of <jats:italic>L.\u00a0indica<\/jats:italic> on hair growth have been studied in human hair follicle dermal papillary (hHFDP) cells and follicular organ culture ex vivo by cell proliferation assay, PCR, western blot analysis, and reporter gene activity assay. Moreover, a clinical trial was conducted in healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>Lagerstroemia indica<\/jats:italic> significantly promoted the proliferation of hHFDP cells, which was associated with increased expression of TCF\/LEF, VEGF, and Gli1 mRNA, and inhibition of STAT6 and Smad2 mRNA. Treatment with <jats:italic>L.\u00a0indica<\/jats:italic> also increased the TCF\/LEF reporter gene activity but downregulated the SBE\u2010 and STAT6\u2010luciferase activities. The expression of total \u03b2\u2010catenin, CDK4, and CDK2 were elevated, while that of STAT6 and SMAD2\/3 was suppressed upon treatment with <jats:italic>L.\u00a0indica<\/jats:italic>. In human hair follicles organ culture, <jats:italic>L.\u00a0indica<\/jats:italic> significantly inhibited hair follicular degeneration. The clinical trial showed a statistically significant rise in total hair count in test group (<jats:italic>n<\/jats:italic>\u00a0=\u00a024) after 24\u2009weeks of applying the hair tonic enriched with <jats:italic>L.\u00a0indica<\/jats:italic> (141.46\u2009\u00b1\u200921.27 number\/cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We suggest that <jats:italic>L.\u00a0indica<\/jats:italic> extract prevents hair loss as well as stimulate hair growth by regulating the Wnt\u2010\u03b2\u2010catenin, JAK3\u2010STAT6, and TGF\u2010\u03b21\u2010Smad signaling pathways, and may be further developed as a novel functional cosmetic for preventing hair loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15081","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T14:35:13Z","timestamp":1653143713000},"page":"2763-2773","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<i>Lagerstroemia indica<\/i> extract regulates human hair dermal papilla cell growth and degeneration via modulation of \u03b2\u2010catenin, Stat6, and <scp>TGF<\/scp>\u2010\u03b2 signaling pathway"],"prefix":"10.1111","volume":"21","author":[{"given":"Byung Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Science &amp; Engineering Seowon University  Cheongju South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myong Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science &amp; Engineering Seowon University  Cheongju South 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