{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:27Z","timestamp":1791489687610,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Skin radiance products achieve perceivable benefits with different sort of mechanism of action.<\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n To use two non\u2010invasive instrumental devices to evaluate the effectiveness of a cosmetic formula designed to improve skin reflectance while respecting skin integrity.<\/jats:p>\n <\/jats:sec>\n \n Patients and Methods<\/jats:title>\n \n Subjects (\n N<\/jats:italic>\n \u00a0=\u00a043) aged 18\u201350\u2009years old had healthy skin of phototype V\u2013VI and Individual Typology Angle between \u221210\u00b0 and \u221250\u00b0. The treatment was applied twice weekly for 4\u2009weeks on a delineated area of the back, and an adjacent area was left untreated. Instrumental and clinical scoring assessments of treated and untreated skin were performed at baseline and Day 26.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Between baseline and Day 26, reflectance (Delta L*) increased by 1.27 points and was considered as clinically relevant. Dermatologist clinical scoring of radiance significantly improved from 2.6 to 3.6 after 4\u2009weeks of treatment and the Skin Color Chart Clarity level significantly decreased from a score of 15.5 to 14.3, representing a skin reflectance improvement. Conversely, the change between baseline and Day 26 in Mexameter Melanin Density was not clinically different for treated skin versus untreated skin (difference of 2.54). At Day 26, changes from baseline for Mexameter Melanin Density and Delta L* parameters appeared to be uncorrelated (\n r<\/jats:italic>\n \u00a0=\u00a0\u22120.036).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This combination of two non\u2010invasive devices can be useful to confirm that a product can modulate skin reflectance without modifying constitutive pigmentation. The formula tested in this study did not interfere with constitutive melanogenesis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.15086","type":"journal-article","created":{"date-parts":[[2022,5,15]],"date-time":"2022-05-15T09:54:52Z","timestamp":1652608492000},"page":"6021-6026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Combining the use of two non\u2010invasive instruments to confirm that a formula can improve skin luminance while respecting constitutive melanogenesis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-0570","authenticated-orcid":false,"given":"Romain","family":"de Dormael","sequence":"first","affiliation":[{"name":"L'Or\u00e9al Research & Innovation Aulnay sous\u2010bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Gueniche","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research & Innovation Chevilly La Rue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bastien","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research & Innovation Aulnay sous\u2010bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Verschoore","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research & Innovation Clichy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12833"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2007.00144.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12701679"},{"key":"e_1_2_9_5_1","first-page":"72","article-title":"Review of superpotent topical corticosteroids","volume":"6","author":"Stoughton RB","year":"1987","journal-title":"Semin 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