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Cell division cycle\u2010associated protein (CDCA) family has a role in regulating cell proliferation and modulating immune cell and tumor cell proliferation in the tumor microenvironment to regulate tumor oncogenesis, development and affect patient outcomes. However, the differential expression pattern and prognostic value of CDCA factors (CDCAs) have not been clarified. In this study, the role of CDCAs in CM was analyzed by using bioinformatics and found that the transcriptional expressions of CDCA1\/2\/3\/5\/6\/8 were upregulating in CM samples than in normal compares. CM patients with downregulated of CDCA1\/3\/4\/5\/6\/8 and high transcriptional levels of CDCA7 suggest a significantly better prognosis. Furthermore, the significant correlations among the expression of CDCAs and the infiltration of immune cells. In terms of the protein level, we found CDCA8 was upregulated in CM patients. In conclusion, CDCA8 is a powerful prognostic biomarker for CM and can be a novel target for immunotherapy.<\/jats:p>","DOI":"10.1111\/jocd.15091","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T10:48:45Z","timestamp":1652698125000},"page":"6034-6048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Regulators\n                    <scp>CDCA8<\/scp>\n                    as potential targets and biomarkers for the prognosis of human skin cutaneous melanoma"],"prefix":"10.1111","volume":"21","author":[{"given":"Rong","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Shanghai East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianghui","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Shanghai East Hospital Tongji 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