{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:51:15Z","timestamp":1791489075909,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hyperpigmentation is darkened patches or spots on the skin occurred by increased melanin. Undecylenoyl phenylalanine (Sepiwhite\u00ae), as a commercial lipophilic derivative of phenylalanine, is a powerful new brightener that can be used in the treatment of skin pigmentation disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Solid lipid nanoparticles (SLNs) increase the efficiency of hydrophobic drugs. The current study aimed to prepare and characterize SLNs containing Sepiwhite (SEPI\u2010SLN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, an optimized SEPI\u2010SLN formulation was selected by applying the response surface method. In vitro drug loading content, the release profile of SEPI, and cell viability were investigated. The permeation rate of SEPI\u2010SLN was also compared to conventional cream containing Sepiwhite (SEPI\u2010CREAM). Furthermore, the anti\u2010tyrosinase activity of Sepiwhite was also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The optimized formulation showed a spherical morphology with particle size and entrapment efficiency of 218.6\u2009\u00b1\u200911.1\u00a0nm and % 87.31\u2009\u00b1\u20090.65, respectively. Differential scanning calorimetry (DSC) analysis confirmed SEPI\u2010loaded SLN formulation with no drug\u2010lipid incompatibility. The in vitro permeation experiment revealed the enhanced cutaneous uptake of SEPI\u2010SLN. The results also showed that Sepiwhite could stop melanogenesis with inhibition of the tyrosinase enzyme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings confirm that SLNs could be a proper nanocarrier for the relevant usage of Sepiwhite as a powerful brightener agent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15102","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T08:22:46Z","timestamp":1653034966000},"page":"6061-6071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preparation, characterization, and evaluation of anti\u2010tyrosinase activity of solid lipid nanoparticles containing Undecylenoyl phenylalanine (Sepiwhite\u00ae)"],"prefix":"10.1111","volume":"21","author":[{"given":"Homa","family":"Kabiri","sequence":"first","affiliation":[{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Tayarani\u2010Najaran","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pouria","family":"Rahmanian\u2010devin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadeseh Sadat","family":"Vaziri","sequence":"additional","affiliation":[{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad 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