{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:45Z","timestamp":1791492645850,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Acral lesions of vitiligo are most likely recalcitrant to the known lines of treatment. Ablative fractional CO\n                      <jats:sub>2<\/jats:sub>\n                      has shown efficacy in treatment of vitiligo in combination with other modalities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty non\u2010segmental vitiligo patients with acral lesion were included in the study. Each patient was subjected to fractional Carbon Dioxide Laser Treatment followed by application of 5 fluorouracil (5FU) cream for five consecutive days. Evaluation was done 3\u2009weeks from the start of treatment and 12\u2009weeks after the last treatment session using VESTA score, evaluation of patients' photos by blinded investigation in addition to patients' satisfaction scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients showed significant improvement of Vitiligo extent score for a target area\n                      <jats:bold>(<\/jats:bold>\n                      VESTA) score and developed considerable degree of repigmentation as assessed by blinded investigators.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The combination of fractional ablative CO\n                      <jats:sub>2<\/jats:sub>\n                      and 5FU is an effective and safe procedure for the treatment of acral vitiligo with promising results offering patients a new therapeutic window.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15116","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:25:14Z","timestamp":1653636314000},"page":"5636-5641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy and safety of combined fractional ablative\n                    <scp>\n                      CO\n                      <sub>2<\/sub>\n                    <\/scp>\n                    laser and 5 fluorouracil in the treatment of acral vitiligo: An open, uncontrolled study"],"prefix":"10.1111","volume":"21","author":[{"given":"Ragia","family":"Weshahy","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Research Department Medical Research and Clinical Studies Institute\u2010 National Research Center  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud F.","family":"Abdelhamid","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Research Department Medical Research and Clinical Studies Institute\u2010 National Research Center  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5220-8511","authenticated-orcid":false,"given":"Khadiga S.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Dermatology Department, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman\u00a0D.","family":"El Desouky","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics NCI, Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahenda A.","family":"Ramez","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Research Department Medical Research and Clinical Studies Institute\u2010 National Research Center  Cairo 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