{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:38:36Z","timestamp":1789810716045,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse events (AE) after COVID\u201019 vaccines, particularly, but not solely, with those messenger RNA (mRNA)\u2010based vaccines, have rarely been reported in patients previously treated with dermal fillers (DF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the morphology, clinical characteristics, the timing of presentation, and outcomes of inflammatory AE appeared in patients injected with DF, after anti\u2010COVID\u201019 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Descriptive study of a case series of 20 consecutive patients collected after the occurrence of AE in previously filled areas post COVID\u201019 vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From January 2021 to July 2021, we analyzed 20 AE reactions triggered by COVID\u201019 vaccines in the previously mentioned cohort. They were vaccinated with Pfizer\/Biontech (11; 55%), Moderna (5; 25%), Astra\u2010Zeneca (3; 15%), and Sputnik (1; 5%). The most common manifestations were oedema\/swelling, angioedema, erythema, skin induration, and granuloma. Less common reactions included myalgia and lymphadenopathy. In 13\/20 (65%) cases, the AE appeared after the first dose of vaccine. These inflammatory AE appeared more rapidly after the second dose than after the first one. In 13\/20 (65%) cases, the symptomatology subsided with anti\u2010inflammatory\/antihistaminic drugs, while spontaneously in 3\/20 (15%). The manifestations are ongoing.in the remaining four cases (20%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although probably rare, both RNA\u2010based and adenovirus\u2010based anti\u2010COVID\u201019 vaccines can cause inflammatory bouts in patients previously treated with DF. In these cases, caution should be paid on subsequent vaccine doses, considering a tailored risk\/benefit for any case before next vaccination.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.15117","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T11:26:01Z","timestamp":1653650761000},"page":"3181-3187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inflammatory immune\u2010mediated adverse reactions induced by <scp>COVID<\/scp>\u201019 vaccines in previously injected patients with soft tissue fillers: A case series of 20 patients"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9212-3619","authenticated-orcid":false,"given":"Jaume","family":"Alijotas\u2010Reig","sequence":"first","affiliation":[{"name":"Systemic Autoimmune Disease Unit, Service of Internal Medicine Vall d\u2019Hebron University Hospital  Barcelona Spain"},{"name":"Department of Medicine, Faculty of Medicine Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Garc\u00eda\u2010GImenez","sequence":"additional","affiliation":[{"name":"Europe Medical Centre  Barcelona Spain"},{"name":"Sociedad Espa\u00f1ola de Medicina y Cirug\u00eda Cosm\u00e9tica  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Velthuis","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Niessen","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Amsterdam UMC, Vrije Universiteit  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom S.","family":"Decates","sequence":"additional","affiliation":[{"name":"Department of Dermatology Erasmus Medical Center  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"American Sociey for Dermatologic Surgery. ASDS members performed nearly 14 milluions treatments in 2019. Available from:https:\/\/www.asds.net\/medical\u2010professionals\/practice\u2010resources\/asds\u2010survey\u2010on\u2010dermatologic\u2010procedures"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/147641700510037716"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.02.001"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2020.01.066"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.5.637"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00114"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.08.003"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2180-5"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03120-0"},{"key":"e_1_2_10_12_1","unstructured":"US Food and Drug Administration.Moderna COVID\u201019 vaccine emergency use authorization. 2020 [cited December 22 2020]. 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