{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:52:30Z","timestamp":1791489150008,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Detect the expression of Interleukin\u20106 (IL\u20106) in the serum of patients with systemic sclerosis (SSc) and assess its association with clinical and laboratory features of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The clinical data from 50 patients with SSc in the affiliated hospital of Xuzhou Medical University, China were retrospectively analyzed. The level of IL\u20106 in peripheral blood of systemic sclerosis patients was compared between the different clinical phenotypes groups. Spearman correlation test was used to analyze the correlation of the IL\u20106 with C\u2010reactive protein (CRP), erythrocyte sedimentation rate (ESR), creatinine, and cystatin C.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Interleukin\u20106 increased in the disease course \u22655\u2009years, systemic sclerosis\u2010Interstitial lung disease (SSc\u2010ILD), pulmonary arterial hypertension (PAH), gastrointestinal involvement, and cardiac involvement group compared with the group with disease course &lt;5\u2009years, no SSc\u2010ILD, PAH, gastrointestinal involvement, and no cardiac involvement group. The differences were statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.05). Correlation analysis showed that IL\u20106 in the group with disease course \u22655\u2009years had a positive correlation with ESR (Rs\u00a0=\u00a00.438,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.022) and CRP (Rs\u00a0=\u00a00.825, P\u2009&lt;\u20090.001), whereas it was negatively correlated with creatinine (Rs\u00a0=\u00a0\u22120.481,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.011). Nevertheless, when it came to disease course &lt;5\u2009years, the figures had no statistically significant difference.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum IL\u20106 in patients with systemic sclerosis is related to different clinical phenotypes. IL\u20106 helps to diagnose various phases of diseases, monitor severities of diseases, and predict the prognosis of patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15133","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T04:43:08Z","timestamp":1653885788000},"page":"6086-6091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Peripheral blood\n                    <scp>IL<\/scp>\n                    \u20106 levels in systemic sclerosis patients: Correlation between\n                    <scp>IL<\/scp>\n                    \u20106 levels and clinical phenotypes"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0478-3244","authenticated-orcid":false,"given":"Xiao","family":"Lin","sequence":"first","affiliation":[{"name":"Department of dermatology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of dermatology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tan","family":"Chen","sequence":"additional","affiliation":[{"name":"Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Min","sequence":"additional","affiliation":[{"name":"Department of dermatology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of dermatology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9641-1207","authenticated-orcid":false,"given":"Guan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of dermatology Affiliated Hospital of Xuzhou Medical University  Xuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10020292"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"97","article-title":"Recent treatments of interstitial lung disease with systemic sclerosis","volume":"9","author":"Yasuoka H","year":"2015","journal-title":"Clin Med Insights Circ Respir Pulm Med"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"e_1_2_10_5_1","first-page":"26811","article-title":"Role of circulating endothelial cells in assessing the severity of systemic sclerosis and predicting its clinical worsening","volume":"11","author":"Di Martino ML","year":"2021","journal-title":"Sci Rep\u2010UK"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.640083"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4304"},{"issue":"10","key":"e_1_2_10_8_1","first-page":"1876","article-title":"Elevated levels of platelet derived growth factor and transforming growth factor\u2010beta 1 in bronchoalveolar lavage fluid from patients with scleroderma","volume":"22","author":"Ludwicka A","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V53.6.1043.1043"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780350111"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200955"},{"issue":"2","key":"e_1_2_10_12_1","first-page":"291","article-title":"Peripheral blood mononuclear cells of patients with systemic sclerosis produce increased amounts of interleukin 6 but not transforming growth factor beta 1","volume":"23","author":"Giacomelli R","year":"1996","journal-title":"J Rheumatol"},{"issue":"8","key":"e_1_2_10_13_1","first-page":"1207","article-title":"Mechanisms of pathogenesis in scleroderma. 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