{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:05:56Z","timestamp":1791468356604,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melasma is a common hypermelanosis characterized by symmetrical brownish macules, especially on the face. Histologic analysis demonstrates increased epidermal and dermal melanin. Dermoscopy is useful to estimate the depth of the melanin and may help in the diagnosis and classification of melasma, with therapeutic importance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the diagnostic concordance of dermoscopic classification of epidermal or mixed subtypes of melasma and the correlation between dermoscopic and histopathological findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty\u2010eight women with facial melasma, phototypes III to V, ages between 30 and 61\u2009years were selected. Based on the evaluation of clinical and dermoscopic images, two independent observers classified melasma into epidermal or mixed subtypes. The intra and interobserver concordances were calculated. Histopathological analysis of epidermal melanin extension and maximum number of melanophages per high\u2010power field (400\u00d7; HPF) have been assessed. Association between the melanophages count and the dermoscopic classification was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Intraobserver agreement was 82.1%, and between observers, from 78.6% to 89.3%, according to the Kappa index. Histopathology revealed increased intraepidermal melanin and the presence of dermal melanophages in all the samples. Ten or more melanophages\/HPF was significantly associated with mixed melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate to substantial concordance in the dermoscopic classification of melasma was found, and the correlation between this classification and the dermal melanophages count have been suggested. Intradermal component of every case of melasma should be considered for therapeutic and prognostic purposes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15145","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T04:10:24Z","timestamp":1654661424000},"page":"5887-5894","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Dermoscopic classification of melasma: Concordance study and correlation with the melanophages count"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3146-5399","authenticated-orcid":false,"given":"Luciana","family":"de Abreu","sequence":"first","affiliation":[{"name":"Sector of Dermatology and Post\u2010Graduation Program in General Clinics, University Hospital and School of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1625-0760","authenticated-orcid":false,"given":"Marcia","family":"Ramos\u2010e\u2010Silva","sequence":"additional","affiliation":[{"name":"Sector of Dermatology and Post\u2010Graduation Course in Dermatology, University Hospital and School of Medicine Federal University of Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Pereira","family":"Quintella","sequence":"additional","affiliation":[{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Instituto Nacional de Infectologia Evandro Chagas, FIOCRUZ  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Mota","family":"Bu\u00e7ard","sequence":"additional","affiliation":[{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"},{"name":"Internal Medicine and Dermatology Departments Ipanema Federal Hospital  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9692-7967","authenticated-orcid":false,"given":"Bruna Souza F\u00e9lix","family":"Bravo","sequence":"additional","affiliation":[{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Munck","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Martins Serra","family":"Moreira","sequence":"additional","affiliation":[{"name":"Professor Rubem David Azulay Dermatology Institute Santa Casa da Misericordia do Rio de Janeiro  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.046"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962007000600005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05748.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962010000500003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000154419.18653.2e"},{"key":"e_1_2_11_8_1","first-page":"101","volume-title":"Fundamentos de Dermatologia \u2010 2a Edi\u00e7\u00e3o 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