{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:49:17Z","timestamp":1791492557449,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Miniaturization of the hair follicles is evident on the balding scalp. Approved medications, topical minoxidil, and oral finasteride for the treatment of alopecia sometimes come with undesirable adverse effects. The study was to examine the bioactivity of medicinal plants for finding the promising source of anti\u2010hair loss application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten ethanolic extracts were prepared from\n                      <jats:italic>Acacia concina<\/jats:italic>\n                      (Willd.) DC.,\n                      <jats:italic>Acanthus ebracteatus<\/jats:italic>\n                      Vahl,\n                      <jats:italic>Bridelia ovata<\/jats:italic>\n                      Decne,\n                      <jats:italic>Cleome viscosa<\/jats:italic>\n                      L.,\n                      <jats:italic>Cocos nucifera<\/jats:italic>\n                      L.,\n                      <jats:italic>Hibiscus subdariffla<\/jats:italic>\n                      L.,\n                      <jats:italic>Oryza sativa<\/jats:italic>\n                      L.,\n                      <jats:italic>Terminalia chebula<\/jats:italic>\n                      Retz.,\n                      <jats:italic>Tinospora crispa<\/jats:italic>\n                      (L.) Hook. f. &amp; Thomson and cytotoxic tested on dermal papilla cells using MTT assay. The effect of the extracts on cell cycle was also determined using flow cytometry technique. Anti\u2010inflammatory activity was examined by determining IL\u20101\u03b2 inhibition in RAW 257.4 cells. In vitro study of androgenic and 5\u03b1\u2010reductase inhibitory activities were also determined using MTT assay and enzymatic reaction couple with liquid chromatography\u2013mass spectrometry (LC\u2013MS), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our results revealed that only\n                      <jats:italic>A. ebracteatus<\/jats:italic>\n                      promoted dermal papilla cell proliferation and the S and G2\/M phases in cell cycle.\n                      <jats:italic>A. ebracteatus<\/jats:italic>\n                      also showed inhibitory activity against 5\u03b1\u2010reductase and testosterone in reducing cell viability of the dermal papilla. Moreover,\n                      <jats:italic>A. ebracteatus<\/jats:italic>\n                      extract strongly inhibited LPS\u2010stimulating IL\u20101\u03b2 production in RAW 264.7 cells in a dose\u2010dependent manner.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Our finding indicated that the ethanolic extract of\n                      <jats:italic>A. ebracteatus<\/jats:italic>\n                      is a promising candidate for anti\u2010hair loss treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15148","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T11:49:34Z","timestamp":1654688974000},"page":"6109-6117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of 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