{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:01:37Z","timestamp":1791489697644,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated platelet count (PC), mean platelet volume (MPV), and Platelet Mass Index (PMI) are reported in patients with psoriasis, while platelet activation is associated with psoriasis severity. Available studies examining the relationship between platelet activation markers and psoriasis have mostly focused on psoriasis area severity index. To the best of our knowledge, there is no study examining the relationship between histopathological features of a single psoriatic plaque and platelet activation. The present study examined the relationship between histomorphological findings obtained by morphometric analysis and psoriasis patients' PC, MPV, and PMI values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Morphometric analysis was performed on hematoxylin and eosin\u2010stained preparations of skin biopsies to measure minimum suprapapillary epidermis thickness (SPET\n                      <jats:sub>min<\/jats:sub>\n                      ) and maximum epidermal thickness (ET\n                      <jats:sub>max<\/jats:sub>\n                      ), maximum suprapapillary keratosis thickness (SPKT\n                      <jats:sub>max<\/jats:sub>\n                      ), and maximum keratosis thickness (KT\n                      <jats:sub>max<\/jats:sub>\n                      ). The relationship between PC, MPV, PMI, and morphometric skin biopsy outcomes was evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      While an inverse correlation was found between SPETmin and PC and PMI in cases with psoriasis (\n                      <jats:italic>p<\/jats:italic>\n                      values\u00a0=\u00a00.015 and 0.005,\n                      <jats:italic>r<\/jats:italic>\n                      values\u00a0=\u00a0\u22120.238 and \u22120.271, respectively), no significant correlation was found between SPETmin and MPV (\n                      <jats:italic>p<\/jats:italic>\n                      value\u00a0=\u00a00.600,\n                      <jats:italic>r<\/jats:italic>\n                      value\u00a0=\u00a0\u2212. 052). On the contrary, no significant correlation was found between SPKTmax, ETmax, and KTmax values and platelet parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We assume that an increased risk of platelet activation\u2010related diseases is expected in psoriasis patients displaying histopathological findings of suprapapillary thinning due to increased platelet activation; therefore, it may be beneficial to monitor these patients in terms of such risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15155","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T11:55:05Z","timestamp":1655121305000},"page":"6129-6133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between histomorphological findings and platelet activation in psoriasis"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1097-4592","authenticated-orcid":false,"given":"Meryem \u0130lkay","family":"Eren Karanis","sequence":"first","affiliation":[{"name":"Department of Pathology, Konya City Hospital University of Health Sciences  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"K\u00fc\u00e7\u00fckosmano\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Konya City Hospital University of Health Sciences  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pembe","family":"Oltulu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Meram Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahriye","family":"K\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Department of Pathology, Meram Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lkay","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Meram Faculty of Medicine Necmettin Erbakan University  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5152\/tdd.2011.16","article-title":"Evalution of clinical and sociodemograpic features of patients with psoriasis in the Konya region","volume":"5","author":"Aykol C","year":"2011","journal-title":"Turk Dermatol Derg\u0131s\u0131\u2010Turk J 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