{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:49:59Z","timestamp":1791488999373,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>In this study, we investigate the biological characteristics of ADSCs from patients with progressive hemifacial atrophy (PHA) in vivo and try to explore the theoretical support for cell\u2010assisted lipotransfer in treating patients with PHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ADSCs and exosomes were respectively extracted from patients with PHA and healthy ones. PHA\u2010ADSC was detected the differentiation ability, phenotype, and anoxic resistance. NTA particle size, electron microscopy (TEM), and WB for CD63 and TSG10 were used to detect the exosomes. ADSCs of PHA (PHA\u2010ADSCs) and healthy ones (NORM\u2010ADSCs) mixed with their granular fat, exosomes mixed with PHA\u2010granular fat, and PBS mixed with PHA\u2010granular fat as the control group. The four groups of different grafts were, respectively, transplanted into nude mice, and the fat grafts were dissected and weighed at 2, 4, 8 and 12\u2009w. Weight and volume retention were calculated for each of the four groups. Then, the four groups of fat grafts were tested for hematoxylin\u2013eosin (HE) and immunohistochemical stainings, CD31 for blood vessel formation, CD68 for macrophage infiltration, and perilipin for fat formation, RT\u2010PCR analysis of the APRC5, ATG5, ATG7, ATG12, BAX, PPARG, CDKN1A, and CDKN2A genes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ADSCs in the PHA group had typical phenotypes and multidirectional abilities\n                      <jats:bold>. The<\/jats:bold>\n                      PHA\u2010ADSCs \u2010assisted lipotransfer group, exhibited a weaker droplet formation and lower volume retention rate than the NORM\u2010ADSCs\u2010assisted lipotransfer group but much better than the non\u2010cell\u2010assisted lipotransfer group. Exosome\u2010assisted lipotransfer group showed benefits, too.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PHA\u2010ADSCs\u2010assisted lipotransfer and the exosome\u2010assisted lipotransfer improved the fat survival rate after fat filling in patients with hemifacial atrophy. Cell\u2010assisted and exosome\u2010assisted lipotransfer is an effective method to treat hemifacial atrophy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15162","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T10:04:55Z","timestamp":1655373895000},"page":"6134-6144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Biological characteristics of adipose\u2010derived stem cells from patients with progressive hemifacial atrophy: An in vivo study"],"prefix":"10.1111","volume":"21","author":[{"given":"Qiuni","family":"Gao","sequence":"first","affiliation":[{"name":"Department of plastic and reconstructive surgery, Plastic Surgery Hospital Chinese Acedemy of Medical Sciences And Peking Union Medical College  Beijing 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