{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:50:15Z","timestamp":1791492615139,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007819","name":"Allergan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melasma is an acquired disorder that results in irregular brown patches on the skin that can occur due to hormonal changes. Although pregnancy\u2010induced melasma is usually temporary, it can become a chronic condition, with significant negative impact on quality of life (QoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>Determine the efficacy and tolerability of a topical, non\u2010hydroquinone, non\u2010retinol pigment\u2010correcting serum (LYT2) for the treatment of pregnancy\u2010induced melasma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This 12\u2010week, single\u2010center clinical trial enrolled 34 non\u2010pregnant women who developed mild to severe facial melasma following a previous pregnancy (mean age, 42\u2009years). LYT2 was applied twice daily to facial skin for 12\u2009weeks in addition to a basic skincare regimen. Outcomes included changes from baseline in skin physiology parameters, such as brightness (L*), using objective digital image analysis, investigator\u2010rated Overall Hyperpigmentation scale, Global Improvement, and Melasma Area and Severity Index (MASI), as well as subject\u2010assessed Melasma Quality of Life Scale. Subjects also completed a questionnaire on self\u2010perceived efficacy and attributes of the study product. Tolerability was assessed by the investigators (erythema, scaling, and edema) and subjects (burning\/stinging and itching). Clinical assessments were conducted at baseline and Weeks 4, 8, and 12.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LYT2 provided statistically significant reductions in overall hyperpigmentation scores as early as Week 4 (\u22125.8% change from baseline) and continued through Week 12 (\u221214.6% change from baseline; all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001). Significant improvements in MASI scores and QoL were also achieved following LYT2 treatment, which was well tolerated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LYT2 represents a new efficacious alternative to hydroquinone\u2010based treatments for pregnancy\u2010induced melasma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.15165","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T10:04:57Z","timestamp":1655373897000},"page":"5739-5746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pigmentation control in pregnancy\u2010induced melasma: Clinical assessment of a non\u2010hydroquinone, non\u2010retinol pigment\u2010correcting serum"],"prefix":"10.1111","volume":"21","author":[{"given":"Elizabeth T.","family":"Makino","sequence":"first","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily I.","family":"Jiang","sequence":"additional","affiliation":[{"name":"SGS Stephens Inc  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Stephens","sequence":"additional","affiliation":[{"name":"SGS Stephens Inc  Richardson Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Mikati","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-5847","authenticated-orcid":false,"given":"Rahul C.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Allergan Aesthetics, an AbbVie Company  Irvine California 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